PMID- 27876573
OWN - NLM
STAT- MEDLINE
DCOM- 20170721
LR  - 20231112
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Print)
IS  - 1568-1637 (Linking)
VI  - 34
DP  - 2017 Mar
TI  - Stem cell therapies in age-related neurodegenerative diseases and stroke.
PG  - 39-50
LID - S1568-1637(16)30147-7 [pii]
LID - 10.1016/j.arr.2016.11.002 [doi]
AB  - Aging, a complex process associated with various structural, functional and 
      metabolic changes in the brain, is an important risk factor for neurodegenerative 
      diseases and stroke. These diseases share similar neuropathological changes, such 
      as the formation of misfolded proteins, oxidative stress, loss of neurons and 
      synapses, dysfunction of the neurovascular unit (NVU), reduction of self-repair 
      capacity, and motor and/or cognitive deficiencies. In addition to gray matter 
      dysfunction, the plasticity and repair capacity of white matter also decrease 
      with aging and contribute to neurodegenerative diseases. Aging not only renders 
      patients more susceptible to these disorders, but also attenuates their 
      self-repair capabilities. In addition, low drug responsiveness and intolerable 
      side effects are major challenges in the prevention and treatment of senile 
      diseases. Thus, stem cell therapies-characterized by cellular plasticity and the 
      ability to self-renew-may be a promising strategy for aging-related brain 
      disorders. Here, we review the common pathophysiological changes, treatments, and 
      the promises and limitations of stem cell therapies in age-related 
      neurodegenerative diseases and stroke.
CI  - Published by Elsevier B.V.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Departments of Neurology, Xuanwu Hospital, Capital University of Medicine, 
      Beijing 100053, China.
FAU - Ji, Xunming
AU  - Ji X
AD  - Departments of Neurosurgery, Xuanwu Hospital, Capital University of Medicine, 
      Beijing 100053, China.
FAU - Leak, Rehana K
AU  - Leak RK
AD  - Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, 
      United States.
FAU - Chen, Fenghua
AU  - Chen F
AD  - Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15260, United States.
FAU - Cao, Guodong
AU  - Cao G
AD  - Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15260, United States; Geriatric Research Education and Clinical Centers, VA 
      Pittsburgh Healthcare System, Pittsburgh, PA 15240, United States. Electronic 
      address: caog@upmc.edu.
LA  - eng
GR  - I01 BX002346/BX/BLRD VA/United States
GR  - I01 BX003923/BX/BLRD VA/United States
GR  - R01 NS079345/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20161119
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Brain/metabolism/physiopathology
MH  - Humans
MH  - *Neurodegenerative Diseases/metabolism/therapy
MH  - Neuronal Plasticity/physiology
MH  - Neurons/*physiology
MH  - Oxidative Stress/physiology
MH  - Stem Cell Transplantation/*methods
MH  - *Stroke/metabolism/therapy
MH  - Synapses/metabolism
PMC - PMC5250574
MID - NIHMS832969
OTO - NOTNLM
OT  - Aging
OT  - Neurodegenerative diseases
OT  - Plasticity
OT  - Self-renew
OT  - Stem cell
OT  - Stroke
COIS- All authors have no actual or potential conflicts of interest, including any 
      financial, personal or other relationships with other people or organizations 
      within three years of beginning of the submitted work.
EDAT- 2016/11/24 06:00
MHDA- 2017/07/22 06:00
PMCR- 2018/03/01
CRDT- 2016/11/24 06:00
PHST- 2016/07/10 00:00 [received]
PHST- 2016/09/26 00:00 [revised]
PHST- 2016/11/04 00:00 [accepted]
PHST- 2016/11/24 06:00 [pubmed]
PHST- 2017/07/22 06:00 [medline]
PHST- 2016/11/24 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - S1568-1637(16)30147-7 [pii]
AID - 10.1016/j.arr.2016.11.002 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2017 Mar;34:39-50. doi: 10.1016/j.arr.2016.11.002. Epub 2016 Nov 
      19.