PMID- 2787710
OWN - NLM
STAT- MEDLINE
DCOM- 19890907
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 80
IP  - 2
DP  - 1989 Aug
TI  - HLA-DR/DQ antigens and reactivity to B cell alloantigen D8/17 in Indian patients 
      with rheumatic heart disease.
PG  - 335-40
AB  - D8/17, a B cell alloantigen, and its occurrence with DR/DQ antigens was examined 
      in 54 patients with rheumatic heart disease and matched North Indian controls. 
      Thirty-four patients (62.9%) carried D8/17 as compared with a frequency of 12.5% 
      in controls (chi 2 by Yates', 18.75; p less than 0.0001). A marginally increased 
      frequency of human leukocyte antigen (HLA)-DR3 (44.2% vs. 28.8%) and a 
      significantly reduced frequency of HLA-DR2 (21.1% vs. 46.6%; p less than 0.005) 
      was observed in patients as compared with controls. However, the most significant 
      positive association was observed with HLA-DQw2 (63.4% in patients and 31.5% in 
      controls; chi 2 by Yates', 9.85; p less than 0.005). The DQw2 association was 
      significant only in the D8/17-positive patients. These observations suggest that 
      the disease susceptibility gene in rheumatic heart disease may be nearer to the 
      HLA-DQ locus than to the HLA-DR.
FAU - Taneja, V
AU  - Taneja V
AD  - Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
FAU - Mehra, N K
AU  - Mehra NK
FAU - Reddy, K S
AU  - Reddy KS
FAU - Narula, J
AU  - Narula J
FAU - Tandon, R
AU  - Tandon R
FAU - Vaidya, M C
AU  - Vaidya MC
FAU - Bhatia, M L
AU  - Bhatia ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Antigens, Differentiation, B-Lymphocyte/*genetics
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - India
MH  - Isoantigens/*genetics
MH  - Male
MH  - Phenotype
MH  - Rheumatic Heart Disease/*genetics
EDAT- 1989/08/01 00:00
MHDA- 1989/08/01 00:01
CRDT- 1989/08/01 00:00
PHST- 1989/08/01 00:00 [pubmed]
PHST- 1989/08/01 00:01 [medline]
PHST- 1989/08/01 00:00 [entrez]
AID - 10.1161/01.cir.80.2.335 [doi]
PST - ppublish
SO  - Circulation. 1989 Aug;80(2):335-40. doi: 10.1161/01.cir.80.2.335.