PMID- 27877613
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1468-6996 (Print)
IS  - 1878-5514 (Electronic)
IS  - 1468-6996 (Linking)
VI  - 14
IP  - 5
DP  - 2013 Oct
TI  - Functionalization of polydimethylsiloxane membranes to be used in the production 
      of voice prostheses.
PG  - 055006
LID - 055006
AB  - The voice is produced by the vibration of vocal cords which are located in the 
      larynx. Therefore, one of the major consequences for patients subjected to 
      laryngectomy is losing their voice. In these cases, a synthetic one-way valve set 
      (voice prosthesis) can be implanted in order to allow restoration of speech. Most 
      voice prostheses are produced with silicone-based materials such as 
      polydimethylsiloxane (PDMS). This material has excellent properties, such as 
      optical transparency, chemical and biological inertness, non-toxicity, 
      permeability to gases and excellent mechanical resistance that are fundamental 
      for its application in the biomedical field. However, PDMS is very hydrophobic 
      and this property causes protein adsorption which is followed by microbial 
      adhesion and biofilm formation. To overcome these problems, surface modification 
      of materials has been proposed in this study. A commercial silicone elastomer, 
      Sylgard(TM) 184 was used to prepare membranes whose surface was modified by 
      grafting 2-hydroxyethylmethacrylate and methacrylic acid by low-pressure plasma 
      treatment. The hydrophilicity, hydrophobic recovery and surface energy of the 
      produced materials were determined. Furthermore, the cytotoxicity and 
      antibacterial activity of the materials were also assessed. The results obtained 
      revealed that the PDMS surface modification performed did not affect the 
      material's biocompatibility, but decreased their hydrophobic character and 
      bacterial adhesion and growth on its surface.
FAU - Ferreira, Paula
AU  - Ferreira P
AD  - CIEPQPF, Departamento de Engenharia Quimica, Universidade de Coimbra, Polo II, 
      Pinhal de Marrocos, 3030-790 Coimbra, Portugal.
FAU - Carvalho, Alvaro
AU  - Carvalho A
AD  - CIEPQPF, Departamento de Engenharia Quimica, Universidade de Coimbra, Polo II, 
      Pinhal de Marrocos, 3030-790 Coimbra, Portugal.
FAU - Correia, Tiago Ruivo
AU  - Correia TR
AD  - CICS-UBI, Centro de Investigacao em Ciencias da Saude, Faculdade de Ciencias da 
      Saude, Universidade da Beira Interior, 6200-506 Covilha, Portugal.
FAU - Antunes, Bernardo Paiva
AU  - Antunes BP
AD  - CICS-UBI, Centro de Investigacao em Ciencias da Saude, Faculdade de Ciencias da 
      Saude, Universidade da Beira Interior, 6200-506 Covilha, Portugal.
FAU - Correia, Ilidio Joaquim
AU  - Correia IJ
AD  - CICS-UBI, Centro de Investigacao em Ciencias da Saude, Faculdade de Ciencias da 
      Saude, Universidade da Beira Interior, 6200-506 Covilha, Portugal.
FAU - Alves, Patricia
AU  - Alves P
AD  - CIEPQPF, Departamento de Engenharia Quimica, Universidade de Coimbra, Polo II, 
      Pinhal de Marrocos, 3030-790 Coimbra, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20130927
PL  - United States
TA  - Sci Technol Adv Mater
JT  - Science and technology of advanced materials
JID - 101614420
PMC - PMC5090376
OTO - NOTNLM
OT  - 10.13
OT  - 30.10
OT  - cell adhesion
OT  - plasma surface modification
OT  - polydimethylsiloxane
OT  - voice prosthesis
EDAT- 2013/09/27 00:00
MHDA- 2013/09/27 00:01
PMCR- 2013/09/27
CRDT- 2016/11/24 06:00
PHST- 2013/03/21 00:00 [received]
PHST- 2013/08/26 00:00 [accepted]
PHST- 2016/11/24 06:00 [entrez]
PHST- 2013/09/27 00:00 [pubmed]
PHST- 2013/09/27 00:01 [medline]
PHST- 2013/09/27 00:00 [pmc-release]
AID - TSTA11668639 [pii]
AID - 10.1088/1468-6996/14/5/055006 [doi]
PST - epublish
SO  - Sci Technol Adv Mater. 2013 Sep 27;14(5):055006. doi: 
      10.1088/1468-6996/14/5/055006. eCollection 2013 Oct.