PMID- 27878061
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1941-2789 (Print)
IS  - 1941-2789 (Linking)
VI  - 9
IP  - 9
DP  - 2016 Sep
TI  - Oral Apremilast for the Treatment of Plaque Psoriasis.
PG  - 43-48
AB  - This article provides an update on the use of oral apremilast, a 
      phosphodiesterase-4 (PDE4) inhibitor, for the treatment of plaque psoriasis. 
      Emphasis is placed on safety evaluations, although efficacy considerations are 
      also addressed. Both two-year and three -year data analyses support the favorable 
      safety profile reported in pivotal trials with this agent. Although effective in 
      many study subjects despite baseline characteristics, higher response rates were 
      noted in those with a baseline psoriasis area and severity index (PASI) score <20 
      and in subjects not previously treated with systemic therapy for psoriasis. 
      Gastrointestinal (GI) side effects are the most common adverse events (AEs) 
      reported, especially during the first few weeks of use; recommendations on 
      management of GI AEs are discussed. Psychological AEs appear to be rare, 
      including with prolonged durations of use, and are not clearly associated with 
      the drug itself as depression and suicidal behaviors are common in individuals 
      with psoriasis. Data reported through up to 182 weeks of exposure to apremilast 
      do not support an association with cardiac AEs, emergence of malignancies, 
      enhanced predilection to develop significant opportunistic infections, or 
      reactivation of occult infection, such as tuberculosis.
FAU - Del Rosso, James Q
AU  - Del Rosso JQ
AD  - Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, 
      Nevada; Lakes Dermatology and Del Rosso Dermatology Research, Las Vegas, Nevada.
FAU - Kircik, Leon
AU  - Kircik L
AD  - Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, 
      Nevada; Lakes Dermatology and Del Rosso Dermatology Research, Las Vegas, Nevada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160901
PL  - United States
TA  - J Clin Aesthet Dermatol
JT  - The Journal of clinical and aesthetic dermatology
JID - 101518173
PMC - PMC5110328
EDAT- 2016/11/24 06:00
MHDA- 2016/11/24 06:01
PMCR- 2016/09/01
CRDT- 2016/11/24 06:00
PHST- 2016/11/24 06:00 [entrez]
PHST- 2016/11/24 06:00 [pubmed]
PHST- 2016/11/24 06:01 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
PST - ppublish
SO  - J Clin Aesthet Dermatol. 2016 Sep;9(9):43-48. Epub 2016 Sep 1.