PMID- 27880031
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20180305
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 59
IP  - 5
DP  - 2017 May
TI  - Increased plasma soluble human leukocyte antigen-G in persistent wheezy infants.
PG  - 530-533
LID - 10.1111/ped.13207 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA)-G is a non-classical major 
      histocompatibility complex class I antigen characterized by limited polymorphism 
      in its coding region, unique tissue expression pattern in physiologic conditions 
      and immunomodulatory properties. Recently, the level of soluble (s)HLA-G was 
      found to be higher in atopic asthma and allergic rhinitis, but this remains to be 
      clarified in wheezy infants. The aim of the present study was therefore to 
      investigate sHLA-G in wheezy infants. METHODS: The subjects consisted of infants 
      with persistent wheezing and positive modified asthma predictive index (mAPI; n = 
      30; persistent group) and those with transient wheezing and negative mAPI (n = 
      17; transient group). sHLA-G was measured in plasma using enzyme-linked 
      immunosorbent assay. Total immunoglobulin E (IgE) and eosinophil count were 
      measured, and skin testing was performed with a battery of 13 antigens with 
      appropriate positive and negative controls. RESULTS: sHLA-G was significantly 
      higher in the persistent wheezing (positive mAPI) group compared with the 
      transient wheezing (negative mAPI) group (P = 0.008). There was no significant 
      difference in peripheral blood eosinophil count and total IgE between the groups. 
      CONCLUSIONS: The increased sHLA-G in infants with persistent wheeze suggests that 
      sHLA-G may be able to be used to distinguish persistent from transient wheeze. 
      Further comprehensive studies are needed on this topic.
CI  - (c) 2016 Japan Pediatric Society.
FAU - Tahan, Fulya
AU  - Tahan F
AD  - Department of Pediatric Allergy, School of Medicine, Erciyes University, Kayseri, 
      Turkey.
FAU - Eke Gungor, Hatice
AU  - Eke Gungor H
AD  - Department of Pediatric Allergy, School of Medicine, Erciyes University, Kayseri, 
      Turkey.
FAU - Akar, Himmet Haluk
AU  - Akar HH
AD  - Department of Pediatric Allergy, School of Medicine, Erciyes University, Kayseri, 
      Turkey.
FAU - Saraymen, Berkay
AU  - Saraymen B
AD  - Department of Biochemistry, School of Medicine, Erciyes University, Kayseri, 
      Turkey.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170228
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Biomarkers)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Asthma/blood/complications/*diagnosis/immunology
MH  - Biomarkers/blood
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Decision Support Techniques
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA-G Antigens/*blood
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Respiratory Sounds/*etiology/physiopathology
OTO - NOTNLM
OT  - asthma
OT  - children
OT  - persistent wheeze
OT  - soluble human leukocyte antigen G
EDAT- 2016/11/24 06:00
MHDA- 2018/03/06 06:00
CRDT- 2016/11/24 06:00
PHST- 2016/06/27 00:00 [received]
PHST- 2016/11/06 00:00 [revised]
PHST- 2016/11/14 00:00 [accepted]
PHST- 2016/11/24 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2016/11/24 06:00 [entrez]
AID - 10.1111/ped.13207 [doi]
PST - ppublish
SO  - Pediatr Int. 2017 May;59(5):530-533. doi: 10.1111/ped.13207. Epub 2017 Feb 28.