PMID- 27880789
OWN - NLM
STAT- MEDLINE
DCOM- 20170627
LR  - 20201215
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 11
DP  - 2016
TI  - Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: 
      Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled 
      Trial with Resting State fMRI.
PG  - e0163952
LID - 10.1371/journal.pone.0163952 [doi]
LID - e0163952
AB  - This pilot randomized control trial was designed to examine whether 
      Rumination-Focused Cognitive Behavior Therapy (RFCBT) reduces rumination and 
      residual depressive symptoms among adolescents with a history of Major Depressive 
      Disorder (MDD) who are at risk for relapse. We also examined whether these 
      changes in symptoms were associated with changes in functional connectivity of 
      the posterior cingulate cortex (PCC), a key node in the default mode network 
      (DMN). Thirty-three adolescents (ages 12-18) were randomized to eight weeks of 
      RFCBT or an assessment only (AO) control. Twenty two adolescents successfully 
      completed fMRI scans pre- and post-intervention. Adolescents were recruited from 
      the clinic and community and met criteria for at least one previous episode of 
      MDD and were currently in full or partial remission. An Independent Evaluator 
      interviewed parent and child before and after the eight-week intervention. The 
      left PCC (-5, -50, 36) seed was used to probe resting state functional 
      connectivity of the DMN. Adolescents who received RFCBT demonstrated reduced 
      rumination (F = -2.76, df = 112, p < .01, 95% CI [-4.72,-0.80]) and self-report 
      depression across eight weeks (F = -2.58, df = 113, p < .01, 95% CI [-4.21, 
      -0.94]). Youth who received RFCBT also demonstrated significant decreases in 
      connectivity between the left PCC and the right inferior frontal gyrus (IFG) and 
      bilateral inferior temporal gyri (ITG). Degree of change in connectivity was 
      correlated with changes in self-report depression and rumination. These data 
      suggest that rumination can be reduced over eight weeks and that this reduction 
      is associated with parallel decreases in residual depressive symptoms and 
      decreased functional connectivity of the left PCC with cognitive control nodes. 
      These changes may enhance the ability of vulnerable youth to stay well during the 
      transition to adulthood. TRIAL REGISTRATION: ClinicalTrials.gov NCT01905267.
FAU - Jacobs, Rachel H
AU  - Jacobs RH
AUID- ORCID: 0000-0003-4951-2704
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States of America.
FAU - Watkins, Edward R
AU  - Watkins ER
AD  - Mood Disorders Centre, University of Exeter, Exeter, United Kingdom.
FAU - Peters, Amy T
AU  - Peters AT
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States of America.
FAU - Feldhaus, Claudia G
AU  - Feldhaus CG
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States of America.
FAU - Barba, Alyssa
AU  - Barba A
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States of America.
FAU - Carbray, Julie
AU  - Carbray J
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States of America.
FAU - Langenecker, Scott A
AU  - Langenecker SA
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States of America.
LA  - eng
SI  - ClinicalTrials.gov/NCT01905267
GR  - UL1 RR029879/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161123
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - *Cognitive Behavioral Therapy
MH  - Depression/physiopathology
MH  - Depressive Disorder, Major/physiopathology/*therapy
MH  - Feeding and Eating Disorders of Childhood/pathology
MH  - Female
MH  - Gyrus Cinguli/diagnostic imaging
MH  - Humans
MH  - Interviews as Topic
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Pilot Projects
MH  - Recurrence
MH  - Treatment Outcome
PMC - PMC5120778
COIS- The authors report no biomedical financial interests or potential conflicts of 
      interest.
EDAT- 2016/11/24 06:00
MHDA- 2017/06/28 06:00
PMCR- 2016/11/23
CRDT- 2016/11/24 06:00
PHST- 2016/03/23 00:00 [received]
PHST- 2016/09/13 00:00 [accepted]
PHST- 2016/11/24 06:00 [entrez]
PHST- 2016/11/24 06:00 [pubmed]
PHST- 2017/06/28 06:00 [medline]
PHST- 2016/11/23 00:00 [pmc-release]
AID - PONE-D-16-11707 [pii]
AID - 10.1371/journal.pone.0163952 [doi]
PST - epublish
SO  - PLoS One. 2016 Nov 23;11(11):e0163952. doi: 10.1371/journal.pone.0163952. 
      eCollection 2016.