PMID- 27880898
OWN - NLM
STAT- MEDLINE
DCOM- 20171121
LR  - 20221207
IS  - 2211-1247 (Electronic)
VI  - 17
IP  - 9
DP  - 2016 Nov 22
TI  - HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and 
      HLA-C( *)12:02/C( *)14:03.
PG  - 2210-2220
LID - S2211-1247(16)31510-8 [pii]
LID - 10.1016/j.celrep.2016.10.075 [doi]
AB  - Natural killer (NK) cells control viral infection in part through the interaction 
      between killer cell immunoglobulin-like receptors (KIRs) and their human 
      leukocyte antigen (HLA) ligands. We investigated 504 anti-retroviral (ART)-free 
      Japanese patients chronically infected with HIV-1 and identified two KIR/HLA 
      combinations, KIR2DL2/HLA-C( *)12:02 and KIR2DL2/HLA-C( *)14:03, that impact 
      suppression of HIV-1 replication. KIR2DL2(+) NK cells suppressed viral 
      replication in HLA-C( *)14:03(+) or HLA-C( *)12:02(+) cells to a significantly 
      greater extent than did KIR2DL2(-) NK cells in vitro. Functional analysis showed 
      that the binding between HIV-1-derived peptide and HLA-C( *)14:03 or HLA-C( *)12:02 
      influenced KIR2DL2(+) NK cell activity through reduced expression of the 
      peptide-HLA (pHLA) complex on the cell surface (i.e., reduced KIR2DL2 ligand 
      expression), rather than through reduced binding affinity of KIR2DL2 to the 
      respective pHLA complexes. Thus, KIR2DL2/HLA-C( *)12:02 and KIR2DL2/HLA-C( *)14:03 
      compound genotypes have protective effects on control of HIV-1 through a 
      mechanism involving KIR2DL2-mediated NK cell recognition of virus-infected cells, 
      providing additional understanding of NK cells in HIV-1 infection.
CI  - Copyright A(c) 2016 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Lin, Zhansong
AU  - Lin Z
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Kuroki, Kimiko
AU  - Kuroki K
AD  - Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido 
      University, Kita-ku, Sapporo 060-0812, Japan.
FAU - Kuse, Nozomi
AU  - Kuse N
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Sun, Xiaoming
AU  - Sun X
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Akahoshi, Tomohiro
AU  - Akahoshi T
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Qi, Ying
AU  - Qi Y
AD  - Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos 
      Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, 
      Frederick, MD 21701, USA.
FAU - Chikata, Takayuki
AU  - Chikata T
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Naruto, Takuya
AU  - Naruto T
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Koyanagi, Madoka
AU  - Koyanagi M
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Murakoshi, Hayato
AU  - Murakoshi H
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
FAU - Gatanaga, Hiroyuki
AU  - Gatanaga H
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan; 
      AIDS Clinical Center, National Center for Global Health and Medicine, 
      Shinjuku-ku, Tokyo 162-8655, Japan.
FAU - Oka, Shinichi
AU  - Oka S
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan; 
      AIDS Clinical Center, National Center for Global Health and Medicine, 
      Shinjuku-ku, Tokyo 162-8655, Japan.
FAU - Carrington, Mary
AU  - Carrington M
AD  - Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos 
      Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, 
      Frederick, MD 21701, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 
      02139-3583, USA.
FAU - Maenaka, Katsumi
AU  - Maenaka K
AD  - Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido 
      University, Kita-ku, Sapporo 060-0812, Japan.
FAU - Takiguchi, Masafumi
AU  - Takiguchi M
AD  - Center for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan. 
      Electronic address: masafumi@kumamoto-u.ac.jp.
LA  - eng
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL2 protein, human)
RN  - 0 (Receptors, KIR2DL2)
SB  - IM
MH  - Alleles
MH  - Asian People
MH  - Chronic Disease
MH  - HIV Infections/blood/*immunology/*virology
MH  - HIV-1/immunology/*physiology
MH  - HLA-C Antigens/*metabolism
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Receptors, KIR2DL2/*metabolism
MH  - Viral Load
MH  - Virus Replication
PMC - PMC5184766
MID - NIHMS827657
OTO - NOTNLM
OT  - HIV-1
OT  - HLA-C
OT  - KIR2DL2
OT  - NK cells
COIS- The authors have declared that no conflict of interest exists.
EDAT- 2016/11/24 06:00
MHDA- 2017/11/29 06:00
PMCR- 2016/12/26
CRDT- 2016/11/24 06:00
PHST- 2016/01/04 00:00 [received]
PHST- 2016/09/12 00:00 [revised]
PHST- 2016/10/20 00:00 [accepted]
PHST- 2016/11/24 06:00 [entrez]
PHST- 2016/11/24 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/12/26 00:00 [pmc-release]
AID - S2211-1247(16)31510-8 [pii]
AID - 10.1016/j.celrep.2016.10.075 [doi]
PST - ppublish
SO  - Cell Rep. 2016 Nov 22;17(9):2210-2220. doi: 10.1016/j.celrep.2016.10.075.