PMID- 27881017
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20190529
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 64
IP  - 1
DP  - 2017
TI  - Association between interleukin-18 variants and prostate cancer in Slovak 
      population.
PG  - 148-155
LID - 10.4149/neo_2017_119 [doi]
AB  - Interleukin-18 (IL-18), pro-inflammatory cytokine, plays important role in 
      antitumor immunity. Polymorphisms in the IL-18 gene may lead to its altered 
      production/activity and such modulate susceptibility to prostate cancer. The aim 
      of this study was to evaluate the relationship between the -607 and +105 
      polymorphisms in the IL-18 gene and the risk of prostate cancer development and 
      progression in Slovak population. The study was performed using 425 patients with 
      prostate cancer, 270 patients with benign prostatic hyperplasia (BHP) and 263 
      healthy male controls. The statistically significant association of the -607 AC 
      genotype (OR = 2.24; p < 0.001), CC genotype (OR = 1.86; p = 0.006), as well as C 
      allele (OR = 1.27; p = 0.033) with the higher risk of prostate cancer development 
      was observed. No association of the IL-18 -607 polymorphism and BHP was detected. 
      The subset analysis revealed the significant association of the -607 AC genotype 
      (OR = 2.01; p = 0.008) with development of higher-grade carcinomas (Gleason score 
      >/=7) and the strong association of the -607 AC genotype (OR = 3.11; p < 0.001), CC 
      genotype (OR = 2.96; p < 0.001) as well as C allele (OR = 1.51; p = 0.003) with 
      the higher risk of prostate cancer development in the group of patients with PSA 
      < 10 ng/ml. The -607 AC genotype was also connected with significantly higher 
      IL-18 plasma concentrations. No association between the IL-18 +105 polymorphism 
      and prostate cancer was observed. The analysis of the distribution of the -607 
      and +105 haplotypes showed significant association of the - 607 C/ + 105 A and - 
      607 C/ + 105 C haplotypes with the risk of prostate cancer. This study found that 
      the IL-18 -607 promoter polymorphism could contribute to prostate cancer 
      development in Slovak population. Its presence was also associated with 
      development of higher-grade carcinomas and therefore may influences the prognosis 
      and aggressiveness of the disease.
FAU - Jurecekova, J
AU  - Jurecekova J
FAU - Babusikova, E
AU  - Babusikova E
FAU - Kmetova Sivonova, M
AU  - Kmetova Sivonova M
FAU - Drobkova, H
AU  - Drobkova H
FAU - Petras, M
AU  - Petras M
FAU - Kliment, J
AU  - Kliment J
FAU - Halasova, E
AU  - Halasova E
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Prostatic Neoplasms/*genetics
MH  - Slovakia
OTO - NOTNLM
OT  - interleukin-18
OT  - prostate cancer polymorphism.
EDAT- 2016/11/25 06:00
MHDA- 2019/04/23 06:00
CRDT- 2016/11/25 06:00
PHST- 2016/11/25 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
PHST- 2016/11/25 06:00 [entrez]
AID - 10.4149/neo_2017_119 [doi]
PST - ppublish
SO  - Neoplasma. 2017;64(1):148-155. doi: 10.4149/neo_2017_119.