PMID- 27881842
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20211204
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 62
IP  - 3
DP  - 2017 Mar
TI  - The investigation of the origin of Southern Tunisians using HLA genes.
PG  - 419-429
LID - 10.1038/jhg.2016.146 [doi]
AB  - The south of Tunisia is characterized by marked ethnic diversity, highlighted by 
      the coexistence of native Berbers with Blacks, Jews and Arab-speaking 
      populations. Despite this heterogeneity, genetic anthropology studies 
      investigating the origin of current Southern Tunisians were rarely reported. We 
      examined human leukocyte antigen (HLA) class I (A, B) and class II (DRB1, DQB1) 
      gene profiles of 250 unrelated Southern Tunisians, and compared them with those 
      of Arab-speaking communities, along with Mediterranean and sub-Sahara African 
      populations using genetic distances, neighbor-joining dendrograms, correspondence 
      and haplotype analysis. In total, 137 HLA alleles were detected, which comprised 
      32 HLA-A, 52 HLA-B, 32 DRB1 and 21 DQB1 alleles. The most frequent alleles were 
      HLA-A*02:01(18.02%), HLA-B*50:01 (9.11%), HLA-DRB1*07:01 (22.06%) and 
      HLA-DQB1*02:01 (17.21%). All pairs of HLA loci show significant linkage 
      disequilibrium. The four loci depict negative F(nd) (the normalized deviate of 
      the homozygosity) values indicating an overall trend to balancing selection. 
      Southern Tunisians appear to be closely related to others Tunisian populations 
      including Berbers, North Africans and Iberians. On the contrary, Southern 
      Tunisians were distinct from Palestinian, Lebanese and Jordanian Middle Eastern 
      Arab-speaking population, despite the deep Arab incursions and Arabization that 
      affected Southern Tunisia. In addition, Southern Tunisians were distant from many 
      sub-Saharan communities, evidenced by genetic distance analysis. Collectively, 
      this indicates a limited genetic contribution of Arab invasion and Black caravans 
      on the makeup of Southern Tunisian gene pool.
FAU - Hajjej, Abdelhafidh
AU  - Hajjej A
AD  - Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia.
FAU - Almawi, Wassim Y
AU  - Almawi WY
AD  - Department of Medical Biochemistry, College of Medicine and Medical Sciences, 
      Arabian Gulf University, Manama, Bahrain.
FAU - Hattab, Lasmar
AU  - Hattab L
AD  - Department of Medical Analysis, Regional Hospital of Gabes, Gabes, Tunisia.
FAU - El-Gaaied, Amel
AU  - El-Gaaied A
AD  - Laboratory of Immunogenetics, Department of Biology, University of Tunis El 
      Manar, Tunis, Tunisia.
FAU - Hmida, Slama
AU  - Hmida S
AD  - Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20161124
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Chromosomes, Human/chemistry
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Flow
MH  - Genetic Heterogeneity
MH  - Genetic Loci
MH  - *Genetics, Population
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Heterozygote
MH  - Homozygote
MH  - Human Migration
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - *Phylogeny
MH  - Selection, Genetic
MH  - Tunisia
EDAT- 2016/11/25 06:00
MHDA- 2017/05/16 06:00
CRDT- 2016/11/25 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2016/10/13 00:00 [revised]
PHST- 2016/10/27 00:00 [accepted]
PHST- 2016/11/25 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/11/25 06:00 [entrez]
AID - jhg2016146 [pii]
AID - 10.1038/jhg.2016.146 [doi]
PST - ppublish
SO  - J Hum Genet. 2017 Mar;62(3):419-429. doi: 10.1038/jhg.2016.146. Epub 2016 Nov 24.