PMID- 27882053
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1687-8450 (Print)
IS  - 1687-8469 (Electronic)
IS  - 1687-8450 (Linking)
VI  - 2016
DP  - 2016
TI  - Hypoxia-Inducible Factor-1alpha Expression in Indonesian Laryngeal Squamous Cell 
      Carcinoma Patients.
PG  - 3215463
LID - 3215463
AB  - Objectives. This research aimed to determine the association between 
      hypoxia-inducible factor-1alpha (HIF-1alpha) expression and laryngeal squamous cell 
      carcinoma clinical stage. Methods. We retrospectively analyzed paraffin-embedded 
      tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 
      2014. HIF-1alpha expression was analyzed by immunohistochemistry using an anti-HIF-1alpha 
      mouse monoclonal antibody. The association between HIF-1alpha expression and clinical 
      stage was analyzed using the chi square test. Results. The glottis was the 
      predominant site of laryngeal squamous cell carcinoma occurrence, and 43/47 
      (91.5%) patients presented at an advanced stage. Of the advanced stage patients, 
      27/43 stained positive for HIF-1alpha expression and 16/43 stained negative. Of the 
      early stage patients, 2/4 stained positive for HIF-1alpha expression and 2/4 stained 
      negative. Statistical analysis did not demonstrate significant association of 
      HIF-1alpha expression. Conclusion. There was no statistically significant association 
      between HIF-1alpha expression and the clinical stage or histological differentiation 
      of LSCC.
FAU - Surono, Agus
AU  - Surono A
AUID- ORCID: 0000-0003-3363-4563
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
FAU - Priyanto, Priyanto
AU  - Priyanto P
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
FAU - Indrasari, Sagung Rai
AU  - Indrasari SR
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20161101
PL  - Egypt
TA  - J Oncol
JT  - Journal of oncology
JID - 101496537
PMC - PMC5108852
EDAT- 2016/11/25 06:00
MHDA- 2016/11/25 06:01
PMCR- 2016/11/01
CRDT- 2016/11/25 06:00
PHST- 2016/08/16 00:00 [received]
PHST- 2016/10/06 00:00 [revised]
PHST- 2016/10/16 00:00 [accepted]
PHST- 2016/11/25 06:00 [entrez]
PHST- 2016/11/25 06:00 [pubmed]
PHST- 2016/11/25 06:01 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - 10.1155/2016/3215463 [doi]
PST - ppublish
SO  - J Oncol. 2016;2016:3215463. doi: 10.1155/2016/3215463. Epub 2016 Nov 1.