PMID- 27882107
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 12
IP  - 5
DP  - 2016 Nov
TI  - Effects of sitagliptin as initial therapy in newly diagnosed elderly type 2 
      diabetics: A randomized controlled study.
PG  - 3002-3008
AB  - The objective of this study was to investigate the characteristics of blood 
      glycemic excursion, incretins and pancreatic hormone secretion in elderly people 
      with newly diagnosed type 2 diabetes mellitus (T2DM) and to study the effects of 
      sitagliptin on glycemic excursion in these subjects. A total of 129 newly 
      diagnosed T2DM patients were enrolled in the study from March 2012 to August 
      2013. Clinical data, serum incretin, pancreatic hormone and continuous glucose 
      monitoring data were collected. Among these subjects, elderly patients (NEDM) 
      randomly received metformin combined with sitagliptin phosphate or glimepiride 
      for 24 weeks. The blood glucose, glycosylated hemoglobin A(1c) (GHbA(1c)), serum 
      incretins and pancreatic hormone levels were determined. During the oral glucose 
      tolerance test (OGTT), 30 min insulin and C-peptide levels, 120 min insulin 
      levels and ratio of the increases of insulin and blood glucose levels after 30 
      min of sugar loading (∆Ins30/∆Glu30) were significantly lower in elderly patients 
      than in middle-aged patients (P<0.05). In addition, the glucagon elevation at 30 
      min was higher and the glucagon-like peptide-1 (GLP-1) at 30 min was lower in the 
      elderly patients (P<0.05). Glucose excursion indices, including the standard 
      deviation of the average blood glucose, intraday mean average glucose excursions 
      (MAGE), and mean of daily differences (MODD), were significantly higher in the 
      elderly patients (P<0.05). During the OGTT, insulin, C-peptide and ∆Ins30/∆Glu30 
      results at 30 min and GLP-1 levels at 120 min in NEDM subjects were significantly 
      increased (P<0.05) and glucagon levels at 30 min was significantly lower after 
      sitagliptin treatment (P<0.05) compared with glimepiride. Moreover, MAGE and MODD 
      were significantly lower in the sitagliptin group after treatment compared to 
      those in the glimepiride group (P<0.05). No severe hypoglycemia or cardiovascular 
      diseases were observed. Strong blood glucose excursions occur in elderly patients 
      with newly diagnosed T2DM. Sitagliptin phosphate combined with metformin 
      effectively and safely improves glycemic excursion and carbohydrate metabolism in 
      NEDM patients by promoting the first phase of insulin and incretin secretion and 
      inhibiting glucagon secretion of.
FAU - Xiao, Xiaoyan
AU  - Xiao X
AD  - Department of Nephrology, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Cui, Xiaopei
AU  - Cui X
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Zhang, Jianbo
AU  - Zhang J
AD  - Department of Emergency, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Han, Zhenxia
AU  - Han Z
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Xiao, Yu
AU  - Xiao Y
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Chen, Nan
AU  - Chen N
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Li, Baoying
AU  - Li B
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Cheng, Mei
AU  - Cheng M
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Gao, Haiqing
AU  - Gao H
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Tang, Kuanxiao
AU  - Tang K
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160920
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5103735
OTO - NOTNLM
OT  - elderly
OT  - glycemic excursion
OT  - incretins
OT  - sitagliptin
OT  - type 2 diabetes
EDAT- 2016/11/25 06:00
MHDA- 2016/11/25 06:01
PMCR- 2016/09/20
CRDT- 2016/11/25 06:00
PHST- 2015/05/21 00:00 [received]
PHST- 2016/09/06 00:00 [accepted]
PHST- 2016/11/25 06:00 [entrez]
PHST- 2016/11/25 06:00 [pubmed]
PHST- 2016/11/25 06:01 [medline]
PHST- 2016/09/20 00:00 [pmc-release]
AID - ETM-0-0-3729 [pii]
AID - 10.3892/etm.2016.3729 [doi]
PST - ppublish
SO  - Exp Ther Med. 2016 Nov;12(5):3002-3008. doi: 10.3892/etm.2016.3729. Epub 2016 Sep 
      20.