PMID- 27883041
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Nov 24
TI  - Interaction between beta-hexachlorocyclohexane and ADIPOQ genotypes contributes to 
      the risk of type 2 diabetes mellitus in East Chinese adults.
PG  - 37769
LID - 10.1038/srep37769 [doi]
LID - 37769
AB  - Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to 
      the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin 
      is considered as an important gene for T2DM. However, the role of ADIPOQ-HCH 
      interaction on T2DM risk remains unclear. Thus, a paired case-control study was 
      conducted in an East Chinese community. A total of 1446 subjects, including 723 
      cases and 723 controls matched on age, gender and residence, were enrolled, and 4 
      types of HCH isomers were measured in serum samples using GC-MS/MS. Additionally, 
      4 candidate ADIPOQ SNPs (rs182052, rs266729, rs6810075, and rs16861194) were 
      genotyped by TaqMan assay, and plasma adiponectin was measured using ELISA. No 
      associations between 4 SNPs and T2DM risk were found, but T2DM risk significantly 
      increased with serum levels of beta-HCH (P < 0.001). Furthermore, the synergistic 
      interaction between beta-HCH and rs182052 significantly increased T2DM risk (OR 
      (I-additive model) = 2.20, OR (I-recessive model) = 2.13). Additionally, 
      individuals carrying only rs182052 (A allele) with high levels of beta-HCH had 
      significant reduction in adiponectin levels (P = 0.016). These results indicate 
      that the interaction between rs182052 and beta-HCH might increase the risk of T2DM 
      by jointly decreasing the adiponectin level and potentially trigger T2DM 
      development.
FAU - Li, Shushu
AU  - Li S
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
AD  - State Key Lab of Reproductive Medicine, Institute of Toxicology, Nanjing Medical 
      University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Wang, Xichen
AU  - Wang X
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Yang, Lu
AU  - Yang L
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
AD  - State Key Lab of Reproductive Medicine, Institute of Toxicology, Nanjing Medical 
      University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Yao, Shen
AU  - Yao S
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
AD  - State Key Lab of Reproductive Medicine, Institute of Toxicology, Nanjing Medical 
      University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Zhang, Ruyang
AU  - Zhang R
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Xiao, Xue
AU  - Xiao X
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Zhang, Zhan
AU  - Zhang Z
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
AD  - State Key Lab of Reproductive Medicine, Institute of Toxicology, Nanjing Medical 
      University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Wang, Li
AU  - Wang L
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
FAU - Xu, Qiujin
AU  - Xu Q
AD  - Lake Research Center, Chinese Research Academy of Environmental Sciences, 8 
      Dayangfang, Anwai Beiyuan, Beijing 100012, P. R. China.
FAU - Wang, Shou-Lin
AU  - Wang SL
AD  - Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, 
      Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
AD  - State Key Lab of Reproductive Medicine, Institute of Toxicology, Nanjing Medical 
      University, 101 Longmian Avenue, Nanjing 211166, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161124
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Adiponectin/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*etiology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Hexachlorocyclohexane/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Risk
MH  - Tandem Mass Spectrometry/methods
PMC - PMC5121886
COIS- The authors declare no competing financial interests.
EDAT- 2016/11/25 06:00
MHDA- 2018/05/22 06:00
PMCR- 2016/11/24
CRDT- 2016/11/25 06:00
PHST- 2016/08/16 00:00 [received]
PHST- 2016/11/01 00:00 [accepted]
PHST- 2016/11/25 06:00 [entrez]
PHST- 2016/11/25 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2016/11/24 00:00 [pmc-release]
AID - srep37769 [pii]
AID - 10.1038/srep37769 [doi]
PST - epublish
SO  - Sci Rep. 2016 Nov 24;6:37769. doi: 10.1038/srep37769.