PMID- 27883931
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20180115
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 150
DP  - 2017 Feb 1
TI  - Disassembly of amphiphilic small molecular prodrug with fluorescence switch 
      induced by pH and folic acid receptors for targeted delivery and controlled 
      release.
PG  - 50-58
LID - S0927-7765(16)30802-5 [pii]
LID - 10.1016/j.colsurfb.2016.11.021 [doi]
AB  - We develop a new type of pH-responsive amphiphilic small molecular prodrug by 
      conjugating folic acid with anti-tumour doxorubicin via a hydrazone bond. This 
      prodrug is featured by high and precise drug loading (55.4wt%), which can 
      self-assemble into micellar nanoparticles in neutral environment while 
      disassemble in the presence of tumour cells expressing folic acid receptors or 
      the acidic tumoral endosomal environment. The prodrug nanoparticles can 
      effectively improve anticancer efficacy due to the features of pH-triggered drug 
      release and targeted delivery. Moreover, in vitro cell study further indicated 
      that the resulting prodrug nanoparticles had enhanced cytotoxicity for 
      folic-acid-positive cells (HeLa) compared to folic-acid-negative cells (MCF-7). 
      More importantly, the induced disassembly of prodrug nanoparticles can "switch 
      on" the inherent fluorescence of the internalized doxorubicin drug in the tumour 
      microenvironment, which can be used for the detection of tumour cells. We believe 
      that this strategy can pave a new way for designing small molecular drug delivery 
      systems and facilitate tumour diagnosis and treatment simultaneously.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Xu, Zhigang
AU  - Xu Z
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University, Chongqing 400715, PR China; Chongqing Key 
      Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 
      400715, PR China. Electronic address: zgxu@swu.edu.cn.
FAU - Shi, Xiaoxiao
AU  - Shi X
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University, Chongqing 400715, PR China; Chongqing Key 
      Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 
      400715, PR China.
FAU - Hou, Meili
AU  - Hou M
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University, Chongqing 400715, PR China; Chongqing Key 
      Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 
      400715, PR China.
FAU - Xue, Peng
AU  - Xue P
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University, Chongqing 400715, PR China; Chongqing Key 
      Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 
      400715, PR China.
FAU - Gao, Yong-E
AU  - Gao YE
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University, Chongqing 400715, PR China; Chongqing Key 
      Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 
      400715, PR China.
FAU - Liu, Shiying
AU  - Liu S
AD  - School of Chemical and Biomedical Engineering, Nanyang Technological University, 
      62 Nanyang Drive, Singapore 637459, Singapore.
FAU - Kang, Yuejun
AU  - Kang Y
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University, Chongqing 400715, PR China; Chongqing Key 
      Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 
      400715, PR China. Electronic address: yjkang@swu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20161117
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Folate Receptors, GPI-Anchored)
RN  - 0 (Hydrazones)
RN  - 0 (Micelles)
RN  - 0 (Prodrugs)
RN  - 80168379AG (Doxorubicin)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Antineoplastic Agents/chemistry
MH  - Delayed-Action Preparations/chemistry
MH  - Doxorubicin/chemistry
MH  - *Drug Delivery Systems
MH  - Endosomes/metabolism
MH  - Fluorescence
MH  - Folate Receptors, GPI-Anchored/*chemistry
MH  - Folic Acid/*chemistry
MH  - HeLa Cells
MH  - Humans
MH  - Hydrazones/chemistry
MH  - Hydrogen-Ion Concentration
MH  - MCF-7 Cells
MH  - Magnetic Resonance Spectroscopy
MH  - Micelles
MH  - Nanoparticles/chemistry
MH  - Prodrugs/*chemistry
MH  - *Spectrometry, Fluorescence
OTO - NOTNLM
OT  - Cancer therapy
OT  - Controlled release
OT  - Diagnosis
OT  - Drug delivery
OT  - Small molecular prodrug
EDAT- 2016/11/25 06:00
MHDA- 2017/03/30 06:00
CRDT- 2016/11/25 06:00
PHST- 2016/09/03 00:00 [received]
PHST- 2016/11/08 00:00 [revised]
PHST- 2016/11/16 00:00 [accepted]
PHST- 2016/11/25 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
PHST- 2016/11/25 06:00 [entrez]
AID - S0927-7765(16)30802-5 [pii]
AID - 10.1016/j.colsurfb.2016.11.021 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2017 Feb 1;150:50-58. doi: 
      10.1016/j.colsurfb.2016.11.021. Epub 2016 Nov 17.