PMID- 27883979
OWN - NLM
STAT- MEDLINE
DCOM- 20171117
LR  - 20171128
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 228
DP  - 2017 Feb 1
TI  - Low NT-proBNP levels: An early sign for the diagnosis of ischemic heart failure.
PG  - 666-671
LID - S0167-5273(16)33597-5 [pii]
LID - 10.1016/j.ijcard.2016.11.139 [doi]
AB  - BACKGROUND: N-terminal pro-brain natriuretic peptide (NT-proBNP) is seen to be 
      mostly elevated in patients with acute heart failure (AHF). However, cases of AHF 
      presenting with low NT-proBNP levels have been reported. In this study designed 
      to investigate the factors associated with low NT-proBNP levels in AHF patients, 
      we discovered that etiology and related factors have an influence on NT-proBNP 
      levels. METHODS: In this study, 154 AHF patients met the study criteria (117 men, 
      median age 74years; left ventricular ejection fraction [LVEF] 46+/-13%; New York 
      Heart Association [NYHA] classes II-IV). We analyzed the different clinical 
      variables of patients based on plasma NT-proBNP levels. In addition, we 
      identified the differences in NT-proBNP levels between ischemic and non-ischemic 
      etiologies, as well as the relationships between time from symptom onset to ED 
      visit and NT-proBNP levels. RESULTS: The group with low NT-proBNP levels showed 
      an ischemic association, higher LVEF, lower NYHA class and shorter time from 
      symptom onset to ED visit. Plasma NT-proBNP levels were lower in the ischemic 
      group than in the non-ischemic group (P<0.01). Meanwhile, NT-proBNP levels were 
      relatively low in patients during early phases of AHF hospitalization and 
      increased with time from symptom onset to ED visit (P<0.01). CONCLUSION: We 
      inferred that low NT-proBNP levels may infer the ischemic etiology especially in 
      patients with normal LVEF in the early phases of AHF hospitalization.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Zheng, Ya-Ru
AU  - Zheng YR
AD  - Department of Cardiology, Zhejiang Provincial People's Hospital, China.
FAU - Ye, Li-Fang
AU  - Ye LF
AD  - Department of Cardiology, Zhejiang Provincial People's Hospital, China.
FAU - Cen, Xue-Jiang
AU  - Cen XJ
AD  - Department of Cardiology, Zhejiang Provincial People's Hospital, China.
FAU - Lin, Jing-Yang
AU  - Lin JY
AD  - Department of Cardiology, Zhejiang Provincial People's Hospital, China.
FAU - Fu, Jian-Wei
AU  - Fu JW
AD  - Department of Cardiology, Zhejiang Provincial People's Hospital, China.
FAU - Wang, Li-Hong
AU  - Wang LH
AD  - Department of Cardiology, Zhejiang Provincial People's Hospital, China. 
      Electronic address: wanglhnew@126.com.
LA  - eng
PT  - Journal Article
DEP - 20161109
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers
MH  - Cohort Studies
MH  - Emergency Service, Hospital
MH  - Female
MH  - Heart Failure/*blood/*diagnosis/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*blood/complications/*diagnosis
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Stroke Volume
OTO - NOTNLM
OT  - Acute heart failure
OT  - Ischemic etiology
OT  - N-terminal pro-brain natriuretic peptide
OT  - Time interval
EDAT- 2016/11/25 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/11/25 06:00
PHST- 2016/08/23 00:00 [received]
PHST- 2016/11/06 00:00 [accepted]
PHST- 2016/11/25 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/11/25 06:00 [entrez]
AID - S0167-5273(16)33597-5 [pii]
AID - 10.1016/j.ijcard.2016.11.139 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Feb 1;228:666-671. doi: 10.1016/j.ijcard.2016.11.139. Epub 
      2016 Nov 9.