PMID- 27885066
OWN - NLM
STAT- MEDLINE
DCOM- 20170524
LR  - 20190131
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Print)
IS  - 0042-4900 (Linking)
VI  - 180
IP  - 1
DP  - 2017 Jan 7
TI  - Effects in dogs with behavioural disorders of a commercial nutraceutical diet on 
      stress and neuroendocrine parameters.
PG  - 18
LID - 10.1136/vr.103865 [doi]
AB  - The well-being of dogs can be affected by changes in human lifestyle, eating 
      habits and increased stressors that lead to behavioural disorders including fear, 
      hyperactivity and anxiety, followed by negative affective moods and poor welfare. 
      This randomised, controlled clinical evaluation involved 69 dogs, 38 males and 31 
      females, of different breeds, with behavioural disorders related to anxiety and 
      chronic stress. They were fed a control diet or a nutraceutical diet (ND group) 
      for 45 days. Neuroendocrine (serotonin, dopamine, beta-endorphins, noradrenaline and 
      cortisol) and stress (derivatives of reactive oxygen metabolites (dROMs) and 
      biological antioxidant potential (BAP)) parameters related to behavioural 
      disorders were evaluated at the beginning and end of the study period. Results 
      showed a significant increase in serotonin, dopamine and beta-endorphins plasma 
      concentrations (*P<0.05, *P<0.05 and **P<0.01, respectively) and a significant 
      decrease in noradrenaline and cortisol plasma concentrations in the ND group 
      (*P<0.05). dROMs significantly decreased in the ND group (*P<0.05) while BAP was 
      not affected. This study demonstrated for the first time that a specific diet 
      significantly and positively affected neuroendocrine parameters and dROMs. These 
      results open significant perspectives concerning the use of diet and 
      nutraceuticals in the treatment of behavioural disorders.
CI  - British Veterinary Association.
FAU - Sechi, S
AU  - Sechi S
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, 
      University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
FAU - Di Cerbo, A
AU  - Di Cerbo A
AUID- ORCID: 0000-0001-8122-9170
AD  - Department of Biomedical Sciences, School of Specialization in Clinical 
      Biochemistry, "G. d'Annunzio" University, Via dei Vestini 31, 66100 Chieti, 
      Italy.
FAU - Canello, S
AU  - Canello S
AD  - Research and Development Department, Forza10 USA Corp., 10142 Canopy Tree Ct. 
      32836 Orlando, Florida, USA.
FAU - Guidetti, G
AU  - Guidetti G
AD  - Research and Development Department, Forza10 USA Corp., 10142 Canopy Tree Ct. 
      32836 Orlando, Florida, USA.
FAU - Chiavolelli, F
AU  - Chiavolelli F
AD  - Department of Diagnostic Medicine, Clinical and Public Health, University of 
      Modena and Reggio Emilia, Via Campi 213/A, 41125 Modena, Italy.
FAU - Fiore, F
AU  - Fiore F
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, 
      University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
FAU - Cocco, R
AU  - Cocco R
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, 
      University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161124
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
CIN - Vet Rec. 2017 May 13;180(19):476-477. PMID: 28500157
CIN - Vet Rec. 2017 May 13;180(19):476. PMID: 28500158
MH  - Animals
MH  - Diet/*veterinary
MH  - *Dietary Supplements
MH  - Dog Diseases/*diet therapy
MH  - Dogs
MH  - Female
MH  - Male
MH  - Mental Disorders/diet therapy/*veterinary
MH  - Neurosecretory Systems
MH  - Oxidative Stress
MH  - Treatment Outcome
PMC - PMC5284471
OTO - NOTNLM
OT  - Neuroendocrine parameters
OT  - anxiety
OT  - behavioral disorders
OT  - chronic stress
OT  - nutraceutical diet
OT  - stress parameters
COIS- This research was performed in collaboration with some scientists from the 
      Division of Research and Development, Sanypet SpA, Padua, Italy (as indicated in 
      the author's affiliation) according to scientific and ethical principles of the 
      scientific community.
EDAT- 2016/11/26 06:00
MHDA- 2017/05/26 06:00
PMCR- 2017/01/31
CRDT- 2016/11/26 06:00
PHST- 2016/10/29 00:00 [accepted]
PHST- 2016/11/26 06:00 [pubmed]
PHST- 2017/05/26 06:00 [medline]
PHST- 2016/11/26 06:00 [entrez]
PHST- 2017/01/31 00:00 [pmc-release]
AID - vr.103865 [pii]
AID - vetrec-2016-103865 [pii]
AID - 10.1136/vr.103865 [doi]
PST - ppublish
SO  - Vet Rec. 2017 Jan 7;180(1):18. doi: 10.1136/vr.103865. Epub 2016 Nov 24.