PMID- 27885341
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2090-214X (Print)
IS  - 2090-2158 (Electronic)
VI  - 2016
DP  - 2016
TI  - Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular 
      Disease in High Risk Patients with Diabetes.
PG  - 7180784
LID - 7180784
AB  - We aimed at comparing the relationship of reduced estimated glomerular filtration 
      rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk 
      patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional 
      study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital. 
      The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 
      without). eGFR was categorized into 6 stages from >90 to <15 mL/min/1.73 m(2). 
      Kidney dysfunction was defined by an eGFR < 60 mL/min/1.73 m(2). Patients with 
      T2D showed a higher prevalence of CVD (37.9% versus 23.6%; P < 0.001) and kidney 
      dysfunction (25% versus 13.2%; P < 0.001) than in the general population. An 
      association with CVD was found with eGFR stages from 30 to 90 mL/min/1.73 m(2) in 
      T2D and from <15 to 90 mL/min/1.73 m(2) in general population, in whom the 
      association of eGFR with coronary heart disease was in an inverse relationship (P 
      < 0.01 for trend). Survival, in diabetes, was lower (P = 0.037) but not 
      associated with kidney dysfunction. Conclusions. In a high risk population, 
      patients admitted to hospital, the relationship of kidney function with CVD is 
      different between T2D and the general population. Competing mortality and the 
      presence of other major risk factors in diabetes may be responsible for this 
      difference.
FAU - Losito, Attilio
AU  - Losito A
AUID- ORCID: 0000-0002-8349-4768
AD  - Renal Unit, Santa Maria Della Misericordia Hospital, Perugia, Italy.
FAU - Pittavini, Loretta
AU  - Pittavini L
AD  - Renal Unit, Santa Maria Della Misericordia Hospital, Perugia, Italy.
FAU - Zampi, Ivano
AU  - Zampi I
AD  - Institute of Geriatrics and Gerontology, Department of Clinical and Experimental 
      Medicine, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, 
      Italy.
FAU - Zampi, Elena
AU  - Zampi E
AD  - Department of Medicine, Hospital of Pantalla, Todi, Italy.
LA  - eng
PT  - Journal Article
DEP - 20161103
PL  - United States
TA  - Int J Nephrol
JT  - International journal of nephrology
JID - 101546753
PMC - PMC5112327
COIS- The authors declare that there are no competing interests regarding the 
      publication of this paper.
EDAT- 2016/11/26 06:00
MHDA- 2016/11/26 06:01
PMCR- 2016/11/03
CRDT- 2016/11/26 06:00
PHST- 2016/07/05 00:00 [received]
PHST- 2016/10/03 00:00 [revised]
PHST- 2016/10/12 00:00 [accepted]
PHST- 2016/11/26 06:00 [entrez]
PHST- 2016/11/26 06:00 [pubmed]
PHST- 2016/11/26 06:01 [medline]
PHST- 2016/11/03 00:00 [pmc-release]
AID - 10.1155/2016/7180784 [doi]
PST - ppublish
SO  - Int J Nephrol. 2016;2016:7180784. doi: 10.1155/2016/7180784. Epub 2016 Nov 3.