PMID- 27885436
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20181202
IS  - 1572-8773 (Electronic)
IS  - 0966-0844 (Linking)
VI  - 30
IP  - 1
DP  - 2017 Feb
TI  - Effects of aluminum trichloride on the cartilage stimulatory growth factors in 
      rats.
PG  - 143-150
LID - 10.1007/s10534-016-9982-9 [doi]
AB  - Aluminum (Al) is considered to be a potentially toxic metal and inhibits 
      cartilage formation. Transforming growth factor beta1 (TGF-beta1) and bone 
      morphogenetic protein 2 (BMP-2) are cartilage stimulatory growth factors, which 
      play important roles in regulating the cartilage formation. To investigate the 
      effects of aluminum trichloride (AlCl(3)) on the regulation of cartilage 
      formation. Eighty Wistar rats were orally exposed to 0 (control group), 0.4 g/L 
      (low-dose group), 0.8 g/L (mid-dose group) and 1.6 g/L (high-dose group) AlCl(3) 
      for 120 days, respectively. The rats body weight were decreased, the cartilage 
      histological structure were disrupted, the cartilage and serum contents of Al and 
      the serum level of C-telopeptide of type II collagen were all increased, the 
      serum level of type II collagen (Col II) and alkaline phosphatase (ALP), and the 
      mRNA expressions of TGF-beta1, BMP-2, ALP and Col II were all decreased in the 
      AlCl(3)-treated groups compared with those in control group. These results 
      indicate that AlCl(3) inhibits the cartilage formation through inhibition of the 
      cartilage stimulatory growth factors expressions.
FAU - Zhang, Fan
AU  - Zhang F
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, China.
FAU - Sun, Xudong
AU  - Sun X
AD  - College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, 
      Jilin, 130062, China.
FAU - Yu, Hongyan
AU  - Yu H
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, China.
FAU - Yang, Xu
AU  - Yang X
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, China.
FAU - Song, Miao
AU  - Song M
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, China.
FAU - Han, Yanfei
AU  - Han Y
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, China.
FAU - Li, Yanfei
AU  - Li Y
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, China. liyanfei@neau.edu.cn.
FAU - Zhu, Yanzhu
AU  - Zhu Y
AD  - Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural 
      Sciences, Changchun, Jilin, 130112, China. zhuyanzhu@caas.cn.
LA  - eng
PT  - Journal Article
DEP - 20161124
PL  - Netherlands
TA  - Biometals
JT  - Biometals : an international journal on the role of metal ions in biology, 
      biochemistry, and medicine
JID - 9208478
RN  - 0 (Aluminum Compounds)
RN  - 0 (Bone Morphogenetic Protein 2)
RN  - 0 (Chlorides)
RN  - 0 (Collagen Type II)
RN  - 0 (Tgfb1 protein, rat)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 3CYT62D3GA (Aluminum Chloride)
RN  - CPD4NFA903 (Aluminum)
SB  - IM
MH  - Aluminum/blood
MH  - Aluminum Chloride
MH  - Aluminum Compounds/pharmacology
MH  - Animals
MH  - Body Weight/drug effects
MH  - Bone Morphogenetic Protein 2/*genetics/metabolism
MH  - Cartilage/drug effects/*growth & development/metabolism
MH  - Chlorides/pharmacology
MH  - Collagen Type II/blood
MH  - Gene Expression Regulation/drug effects
MH  - Rats
MH  - Signal Transduction/drug effects
MH  - Transforming Growth Factor beta1/*genetics/metabolism
OTO - NOTNLM
OT  - Aluminum trichloride
OT  - Cartilage
OT  - Cartilage stimulatory growth factors
OT  - Rat
EDAT- 2016/11/26 06:00
MHDA- 2018/01/03 06:00
CRDT- 2016/11/26 06:00
PHST- 2016/11/10 00:00 [received]
PHST- 2016/11/15 00:00 [accepted]
PHST- 2016/11/26 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2016/11/26 06:00 [entrez]
AID - 10.1007/s10534-016-9982-9 [pii]
AID - 10.1007/s10534-016-9982-9 [doi]
PST - ppublish
SO  - Biometals. 2017 Feb;30(1):143-150. doi: 10.1007/s10534-016-9982-9. Epub 2016 Nov 
      24.