PMID- 27885786
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20181202
IS  - 1542-4758 (Electronic)
IS  - 1492-7535 (Linking)
VI  - 21
IP  - 4
DP  - 2017 Oct
TI  - Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis 
      patients.
PG  - 549-556
LID - 10.1111/hdi.12516 [doi]
AB  - INTRODUCTION: In hemodialysis (HD) patients, one of the common complications is 
      renal anemia. Therefore, the present study was designed to investigate the 
      effects of flaxseed oil consumption on blood hepcidin and hematologic factors in 
      HD patients. METHODS: In this randomized, double-blind, clinical trial, 38 HD 
      patients were randomly assigned to either the flaxseed oil or the control group. 
      The patients in the flaxseed oil group received 6 g/d flaxseed oil for 8 wk, 
      whereas the control group received 6 g/d medium chain triglycerides (MCT) oil. At 
      baseline and the end of week 8, serum hepcidin, and blood hemoglobin, hematocrit, 
      red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular 
      hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were 
      measured after a 12- to 14-h fast. FINDINGS: Flaxseed oil consumption 
      significantly reduced serum hepcidin concentration up to 25% during 8 weeks, and 
      the reduction was significant in comparison with the MCT oil group. In addition, 
      the number of RBCs, blood hemoglobin, hematocrit, MCH and MCHC increased 
      significantly in the flaxseed oil group up to 6%, 10%, 6%, 5%, and 2%, 
      respectively, and these elevations were significant in comparison with the MCT 
      oil group. There was no significant difference between the two groups in mean 
      changes of MCV. DISCUSSION: This study indicates that daily consumption of 6 g 
      flaxseed oil reduces serum hepcidin and improves hematologic factors in HD 
      patients.
CI  - (c) 2016 International Society for Hemodialysis.
FAU - Tabibi, Hadi
AU  - Tabibi H
AD  - Department of Clinical Nutrition & Dietetics, Faculty of Nutrition and Food 
      Technology, National Nutrition and Food Technology Research Institute, Shahid 
      Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
FAU - Mirfatahi, Maryam
AU  - Mirfatahi M
AD  - Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical 
      Sciences, Tehran, Islamic Republic of Iran.
FAU - Hedayati, Mehdi
AU  - Hedayati M
AD  - Cellular and Molecular Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic 
      Republic of Iran.
FAU - Nasrollahi, Alireza
AU  - Nasrollahi A
AD  - Department of Nephrology, Taleghani hospital, Shahid Beheshti University of 
      Medical Sciences, Tehran, Islamic Republic of Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161125
PL  - Canada
TA  - Hemodial Int
JT  - Hemodialysis international. International Symposium on Home Hemodialysis
JID - 101093910
RN  - 0 (Hepcidins)
RN  - 8001-26-1 (Linseed Oil)
SB  - IM
MH  - Aged
MH  - Anemia/*drug therapy
MH  - Double-Blind Method
MH  - Female
MH  - Hepcidins/*blood
MH  - Humans
MH  - Linseed Oil/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Renal Dialysis/*methods
OTO - NOTNLM
OT  - Flaxseed oil
OT  - hematologic factors
OT  - hemodialysis
OT  - hepcidin
OT  - renal anemia
EDAT- 2016/11/26 06:00
MHDA- 2018/03/20 06:00
CRDT- 2016/11/26 06:00
PHST- 2016/11/26 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2016/11/26 06:00 [entrez]
AID - 10.1111/hdi.12516 [doi]
PST - ppublish
SO  - Hemodial Int. 2017 Oct;21(4):549-556. doi: 10.1111/hdi.12516. Epub 2016 Nov 25.