PMID- 27887590
OWN - NLM
STAT- MEDLINE
DCOM- 20170621
LR  - 20181202
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 16
IP  - 1
DP  - 2016 Nov 25
TI  - Comparing the adverse clinical outcomes in patients with non-insulin treated type 
      2 diabetes mellitus and patients without type 2 diabetes mellitus following 
      percutaneous coronary intervention: a systematic review and meta-analysis.
PG  - 238
LID - 238
AB  - BACKGROUND: Several studies showed Type 2 Diabetes Mellitus (T2DM) to be 
      associated with worse adverse clinical outcomes compared to non-T2DM (NDM) 
      following Percutaneous Coronary Intervention (PCI). In addition, patients with 
      insulin-treated T2DM (ITDM) showed worse clinical outcomes compared to patients 
      with non-insulin treated T2DM (NITDM). Since NITDM and NDM have seldom been 
      systematically analyzed, this study aimed to compare the short and long term 
      adverse clinical outcomes observed in patients with NITDM and patients without 
      T2DM following PCI. METHODS: Medline/PubMed, EMBASE and the Cochrane library were 
      searched for Randomized Controlled Trials (RCTs) and observational studies 
      comparing patients with (including ITDM and NITDM) and without T2DM following 
      PCI. Endpoints included adverse clinical outcomes reported during a short and a 
      long term follow up period. Odd Ratios (OR) and 95% Confidence Intervals (CI) in 
      accordance with either a fixed or a random effects model appropriately, were 
      calculated and the pooled analyses were performed with RevMan 5.3. RESULTS: 
      Twelve studies consisting of a total number of 52,451 patients (14,863 NITDM and 
      37,588 NDM) were included. Patients with NITDM were found to have significantly 
      higher short-term Major Adverse Cardiac Events (MACEs) and mortality with OR: 
      1.63, 95% CI (1.17, 2.27); P = 0.004 and OR: 1.71, 95% CI (1.40, 2.10), 
      P < 0.00001 respectively and higher long-term MACEs and mortality with OR: 1.25, 
      95% CI (1.12, 1.40), P = 0.0001 and OR: 1.32, 95% CI (1.19, 1.47), P < 0.00001 
      respectively compared to NDM following PCI. In addition, compared to NDM, 
      long-term Target Vessel Revascularization (TVR) and Target Lesion 
      Revascularization (TLR) were significantly higher in the NITDM group with OR: 
      1.36, 95% CI (1.18, 1.56), P < 0.0001 and OR: 1.32, 95% CI (1.10, 1.59), 
      P = 0.003 respectively. However, even if an increased long-term stent thrombosis 
      was observed in the NITDM group with OR: 1.13; 95% CI (0.91, 1.40), P = 0.28, the 
      result was insignificant. CONCLUSION: Short and long term MACEs and mortality 
      were significantly higher in patients with NITDM compared to patients without 
      diabetes following PCI. Revascularization also significantly favored patients 
      without T2DM. However, stent thrombosis was not significantly different.
FAU - Li, Nuo
AU  - Li N
AD  - Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, 530027, People's Republic of China.
FAU - Yang, Ye-Gui
AU  - Yang YG
AD  - Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, 530027, People's Republic of China.
FAU - Chen, Meng-Hua
AU  - Chen MH
AD  - Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, 530027, People's Republic of China. 
      xyicucmh@sina.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20161125
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Coronary Artery Disease/complications/*surgery
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Global Health
MH  - Humans
MH  - Incidence
MH  - *Percutaneous Coronary Intervention
MH  - Postoperative Complications/*epidemiology
MH  - Prognosis
MH  - Survival Rate/trends
PMC - PMC5124234
OTO - NOTNLM
OT  - Clinical outcomes
OT  - Major adverse cardiac events
OT  - Non-insulin treated diabetes mellitus
OT  - Percutaneous coronary intervention
OT  - Stent thrombosis
EDAT- 2016/11/27 06:00
MHDA- 2017/06/22 06:00
PMCR- 2016/11/25
CRDT- 2016/11/27 06:00
PHST- 2016/04/14 00:00 [received]
PHST- 2016/11/22 00:00 [accepted]
PHST- 2016/11/27 06:00 [entrez]
PHST- 2016/11/27 06:00 [pubmed]
PHST- 2017/06/22 06:00 [medline]
PHST- 2016/11/25 00:00 [pmc-release]
AID - 10.1186/s12872-016-0422-0 [pii]
AID - 422 [pii]
AID - 10.1186/s12872-016-0422-0 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2016 Nov 25;16(1):238. doi: 10.1186/s12872-016-0422-0.