PMID- 27888330
OWN - NLM
STAT- MEDLINE
DCOM- 20171103
LR  - 20230207
IS  - 1863-2300 (Electronic)
IS  - 1863-2297 (Linking)
VI  - 39
IP  - 2
DP  - 2017 Feb
TI  - Dendritic cells in central nervous system autoimmunity.
PG  - 99-111
LID - 10.1007/s00281-016-0608-7 [doi]
AB  - Dendritic cells (DCs) operate at the intersection of the innate and adaptive 
      immune systems. DCs can promote or inhibit adaptive immune responses against 
      neuroantigens. While DC intrinsic properties, i.e., their maturation state or the 
      subset they belong to, are important determinants of the outcome of an autoimmune 
      reaction, tissue-specific cues might also be relevant for the function of DCs. 
      Thus, a better understanding of the performance of distinct DC subsets in 
      specific anatomical niches, not only in lymphoid tissue but also in non-lymphoid 
      tissues such as the meninges, the choroid plexus, and the inflamed CNS 
      parenchyma, will be instrumental for the design of immune intervention strategies 
      to chronic inflammatory diseases that do not put at risk basic surveillance 
      functions of the immune system in the CNS. Here, we will review modern concepts 
      of DC biology in steady state and during autoimmune neuroinflammation.
FAU - Sie, Christopher
AU  - Sie C
AD  - Klinikum rechts der Isar, Department of Neurology and Department of Experimental 
      Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675, 
      Munich, Germany.
FAU - Korn, Thomas
AU  - Korn T
AUID- ORCID: 0000-0002-3633-0955
AD  - Klinikum rechts der Isar, Department of Neurology and Department of Experimental 
      Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675, 
      Munich, Germany. thomas.korn@tum.de.
AD  - Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. 
      thomas.korn@tum.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161125
PL  - Germany
TA  - Semin Immunopathol
JT  - Seminars in immunopathology
JID - 101308769
RN  - 0 (Antigens)
RN  - 0 (Biomarkers)
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/drug effects/immunology/metabolism
MH  - Antigens/immunology
MH  - *Autoimmunity
MH  - Biomarkers
MH  - Central Nervous System/*immunology/*metabolism/pathology
MH  - Dendritic Cells/classification/drug effects/*immunology/*metabolism
MH  - Drug Discovery
MH  - Histocompatibility Antigens/genetics/immunology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Inflammation/immunology/metabolism/pathology
MH  - Lymphoid Tissue/immunology/metabolism
MH  - Mice
MH  - Models, Animal
MH  - Multiple Sclerosis/drug therapy/immunology/metabolism/pathology
MH  - Myelin Sheath/immunology
MH  - Phenotype
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - T-Lymphocytes, Helper-Inducer/immunology/metabolism
OTO - NOTNLM
OT  - Central nervous system
OT  - Dendritic cells
OT  - Experimental autoimmune encephalomyelitis
OT  - Multiple sclerosis
OT  - T helper cells
EDAT- 2016/11/27 06:00
MHDA- 2017/11/04 06:00
CRDT- 2016/11/27 06:00
PHST- 2016/10/17 00:00 [received]
PHST- 2016/11/13 00:00 [accepted]
PHST- 2016/11/27 06:00 [pubmed]
PHST- 2017/11/04 06:00 [medline]
PHST- 2016/11/27 06:00 [entrez]
AID - 10.1007/s00281-016-0608-7 [pii]
AID - 10.1007/s00281-016-0608-7 [doi]
PST - ppublish
SO  - Semin Immunopathol. 2017 Feb;39(2):99-111. doi: 10.1007/s00281-016-0608-7. Epub 
      2016 Nov 25.