PMID- 27888331
OWN - NLM
STAT- MEDLINE
DCOM- 20171103
LR  - 20181113
IS  - 1863-2300 (Electronic)
IS  - 1863-2297 (Print)
IS  - 1863-2297 (Linking)
VI  - 39
IP  - 2
DP  - 2017 Feb
TI  - The origin of DCs and capacity for immunologic tolerance in central and 
      peripheral tissues.
PG  - 137-152
LID - 10.1007/s00281-016-0602-0 [doi]
AB  - Dendritic cells (DCs) are specialized immune sentinels that play key role in 
      maintaining immune homeostasis by efficiently regulating the delicate balance 
      between protective immunity and tolerance to self. Although DCs respond to 
      maturation signals present in the surrounding milieu, multiple layers of 
      suppression also co-exist that reduce the infringement of tolerance against 
      self-antigens. These tolerance inducing properties of DCs are governed by their 
      origin and a range of other factors including distribution, cytokines, growth 
      factors, and transcriptional programing, that collectively impart suppressive 
      functions to these cells. DCs directing tolerance secrete anti-inflammatory 
      cytokines and induce naive T cells or B cells to differentiate into regulatory T 
      cells (Tregs) or B cells. In this review, we provide a detailed outlook on the 
      molecular mechanisms that induce functional specialization to govern central or 
      peripheral tolerance. The tolerance-inducing nature of DCs can be exploited to 
      overcome autoimmunity and rejection in graft transplantation.
FAU - Devi, K Sanjana P
AU  - Devi KS
AD  - Department of Dermatology/Harvard Skin Disease Research Center, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, MA, USA.
FAU - Anandasabapathy, Niroshana
AU  - Anandasabapathy N
AD  - Department of Dermatology/Harvard Skin Disease Research Center, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, MA, USA. 
      Nanandasabapathy@partners.org.
LA  - eng
GR  - P30 AR069625/AR/NIAMS NIH HHS/United States
GR  - R01 AR070234/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161125
PL  - Germany
TA  - Semin Immunopathol
JT  - Seminars in immunopathology
JID - 101308769
RN  - 0 (Cytokines)
RN  - 0 (Hematopoietic Cell Growth Factors)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Vaccines)
RN  - 0 (flt3 ligand protein)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - B-Lymphocytes, Regulatory/immunology/metabolism
MH  - Cell Differentiation
MH  - Cross-Priming/immunology
MH  - Cytokines/metabolism
MH  - Dendritic Cells/classification/cytology/*immunology/*metabolism
MH  - Gene Expression Regulation
MH  - Hematopoietic Cell Growth Factors/metabolism
MH  - Hematopoietic Stem Cells/cytology/metabolism
MH  - Homeostasis
MH  - Humans
MH  - *Immune Tolerance
MH  - Immunomodulation
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Membrane Proteins/metabolism
MH  - Organ Specificity/immunology
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Transcription Factors/metabolism
MH  - Transcription, Genetic
MH  - Vaccines/immunology
PMC - PMC5296242
MID - NIHMS832447
OTO - NOTNLM
OT  - Tolerogenic DCs
OT  - cytokines
OT  - growth factors
OT  - immune homeostasis
OT  - regulatory T cells
OT  - transcription factors
EDAT- 2016/11/27 06:00
MHDA- 2017/11/04 06:00
PMCR- 2018/02/01
CRDT- 2016/11/27 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2016/10/28 00:00 [accepted]
PHST- 2016/11/27 06:00 [pubmed]
PHST- 2017/11/04 06:00 [medline]
PHST- 2016/11/27 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1007/s00281-016-0602-0 [pii]
AID - 10.1007/s00281-016-0602-0 [doi]
PST - ppublish
SO  - Semin Immunopathol. 2017 Feb;39(2):137-152. doi: 10.1007/s00281-016-0602-0. Epub 
      2016 Nov 25.