PMID- 27888642
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20180110
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 7
IP  - 3
DP  - 2017 Mar
TI  - Histamine H4 receptor gene polymorphisms: a potential predictor of oral H1 
      antihistamine efficacy for allergic rhinitis.
PG  - 268-275
LID - 10.1002/alr.21870 [doi]
AB  - BACKGROUND: Our study aimed to investigate the associations between Histamine H4 
      receptor (HRH4) gene polymorphisms (rs77485247, rs74604924, and rs77041280) and 
      oral H1 antihistamine efficacy for the treatment of allergic rhinitis (AR) 
      patients. METHODS: A total of 142 AR patients were selected as a case group and 
      160 healthy individuals were recruited as a control group. Single nucleotide 
      polymorphisms (SNPs) in the HRH4 gene were detected using direct sequencing. 
      Serum immunoglobulin E (IgE), specific IgE, and eosinophil cationic protein (ECP) 
      levels were measured by enzyme-linked immunosorbent assay (ELISA). Clinical 
      efficacy was evaluated by the visual analogue scale (VAS). The occurrence of 
      adverse reaction was recorded. RESULTS: There were significant differences in the 
      distribution frequencies of mutant genotype (TA + AA) and A allele of rs77485247, 
      mutant genotype (AT + TT) and T allele of rs74604924, and mutant genotype (AT + 
      TT) and T allele of rs77041280 between the case and control groups. AR patients 
      with mutant genotype (TA + AA) of rs77485247 and AR patients with mutant genotype 
      (AT + TT) of rs77041280 had higher specific IgE, ECP levels, and VAS scores after 
      treatment and lower incidence of adverse reactions and total effective rate than 
      those with TT genotype and those with AA genotype, respectively. However, for 
      rs74604924, there were no differences was found between AR patients with mutant 
      genotype (AT + TT) and those with AA genotype. CONCLUSION: Our findings provide 
      evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with 
      the risk of AR and the efficacy of H1 antihistamines for the treatment of AR 
      patients.
CI  - (c) 2016 ARS-AAOA, LLC.
FAU - Gu, Jian
AU  - Gu J
AD  - Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine, Shanghai, P.R. China.
FAU - Mao, Xiao-Hui
AU  - Mao XH
AD  - Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine, Shanghai, P.R. China.
FAU - Yang, Xi-Zhi
AU  - Yang XZ
AD  - Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine, Shanghai, P.R. China.
FAU - Ao, Hua-Fei
AU  - Ao HF
AD  - Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine, Shanghai, P.R. China.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine, Shanghai, P.R. China.
FAU - Li, You
AU  - Li Y
AD  - Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine, Shanghai, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161126
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Receptors, Histamine H4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
RN  - EC 3.1.27.- (RNASE3 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Eosinophil Cationic Protein/blood
MH  - Female
MH  - Genotype
MH  - Histamine H1 Antagonists/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Histamine H4/*genetics
MH  - Rhinitis, Allergic/blood/*drug therapy/*genetics
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - H1 antihistamines
OT  - allergic rhinitis
OT  - desloratadine
OT  - efficacy
OT  - histamine H4 receptor
OT  - single nucleotide polymorphism
EDAT- 2016/11/27 06:00
MHDA- 2017/12/05 06:00
CRDT- 2016/11/27 06:00
PHST- 2016/03/31 00:00 [received]
PHST- 2016/09/06 00:00 [revised]
PHST- 2016/10/07 00:00 [accepted]
PHST- 2016/11/27 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2016/11/27 06:00 [entrez]
AID - 10.1002/alr.21870 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2017 Mar;7(3):268-275. doi: 10.1002/alr.21870. Epub 
      2016 Nov 26.