PMID- 27888649 OWN - NLM STAT- MEDLINE DCOM- 20171204 LR - 20210109 IS - 2042-6984 (Electronic) IS - 2042-6976 (Print) IS - 2042-6976 (Linking) VI - 7 IP - 3 DP - 2017 Mar TI - Prospective, multicenter evaluation of balloon sinus dilation for treatment of pediatric chronic rhinosinusitis. PG - 221-229 LID - 10.1002/alr.21889 [doi] AB - BACKGROUND: Although balloon sinus dilation is a treatment option for adults with chronic rhinosinusitis (CRS), there have been few studies performed in pediatric patients. METHODS: This study was designed as a prospective, multicenter, single-arm investigation. Children (2 to 21 years old) with CRS who had failed medical management were treated with balloon sinus dilation and followed to 6 months postprocedure. RESULTS: Fifty children were treated at 4 centers; 33 participants were 2 to 12 years old (mean +/- standard deviation age: 6.6 +/- 2.2 years) and 17 participants were >12 to 21 years (mean age: 15.7 +/- 2.5 years). A total of 157 sinus dilations were attempted (98 maxillary, 30 frontal, and 29 sphenoid sinuses) and all were successful with no complications. Significant improvement in the Sinus and Nasal Quality of Life Survey (SN-5) was seen for all children between baseline and 6 months (4.6 +/- 1.2 vs 1.7 +/- 0.8; p < 0.0001) and 92% improved by a minimal clinically important difference (MCID) of 1.0 or more. Those children aged 2 to 12 years with standalone balloon dilation also showed significant SN-5 improvements between baseline and follow-up (4.5 +/- 1.0 vs 1.9 +/- 0.8; p < 0.0001). Multivariate regression analysis showed no differences or associations of SN-5 improvement at 6 months with the presence of allergy, asthma, or concomitant procedures. For adolescents, overall 22-item Sino-Nasal Outcome Test (SNOT-22) mean scores were also significantly improved at 6 months (42.2 +/- 19.2 vs 10.4 +/- 9.7; p < 0.0001). CONCLUSION: Balloon sinus dilation is safe and appears effective for children with CRS aged 2 years and older. CI - (c) 2016 The Authors International Forum of Allergy & Rhinology, published by ARSAAOA, LLC. FAU - Soler, Zachary M AU - Soler ZM AD - Medical University of South Carolina, Charleston, SC. FAU - Rosenbloom, Jeffrey S AU - Rosenbloom JS AD - Alamo ENT and Associates, San Antonio, TX. FAU - Skarada, Douglas AU - Skarada D AD - Willamette ENT and Facial Plastic Surgery, Salem, OR. FAU - Gutman, Michael AU - Gutman M AD - North Valley ENT, Phoenix, AZ. FAU - Hoy, Mark J AU - Hoy MJ AD - Medical University of South Carolina, Charleston, SC. FAU - Nguyen, Shaun A AU - Nguyen SA AD - Medical University of South Carolina, Charleston, SC. LA - eng SI - ClinicalTrials.gov/NCT02278484 PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20161126 PL - United States TA - Int Forum Allergy Rhinol JT - International forum of allergy & rhinology JID - 101550261 SB - IM CIN - Int Forum Allergy Rhinol. 2017 Jun;7(6):629-630. PMID: 28318142 CIN - Int Forum Allergy Rhinol. 2017 Jun;7(6):631. PMID: 28591472 MH - Adolescent MH - Adult MH - Catheterization/*methods MH - Child MH - Child, Preschool MH - Chronic Disease MH - Dilatation MH - Female MH - Humans MH - Male MH - Paranasal Sinuses MH - Quality of Life MH - Reoperation MH - Rhinitis/*therapy MH - Sinusitis/*therapy MH - Treatment Outcome MH - Young Adult PMC - PMC5363383 OTO - NOTNLM OT - adolescent OT - balloon OT - child OT - chronic, rhinosinusitis OT - outcome OT - quality of life OT - sinuplasty OT - sinusitis OT - surgery OT - therapy EDAT- 2016/11/27 06:00 MHDA- 2017/12/05 06:00 PMCR- 2017/03/23 CRDT- 2016/11/27 06:00 PHST- 2016/04/20 00:00 [received] PHST- 2016/09/20 00:00 [revised] PHST- 2016/10/07 00:00 [accepted] PHST- 2016/11/27 06:00 [pubmed] PHST- 2017/12/05 06:00 [medline] PHST- 2016/11/27 06:00 [entrez] PHST- 2017/03/23 00:00 [pmc-release] AID - ALR21889 [pii] AID - 10.1002/alr.21889 [doi] PST - ppublish SO - Int Forum Allergy Rhinol. 2017 Mar;7(3):221-229. doi: 10.1002/alr.21889. Epub 2016 Nov 26.