PMID- 27888994
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20180205
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 121
DP  - 2016 Dec
TI  - Early life exposure to traffic-related air pollution and allergic rhinitis in 
      preschool children.
PG  - 67-73
LID - S0954-6111(16)30279-7 [pii]
LID - 10.1016/j.rmed.2016.10.016 [doi]
AB  - BACKGROUND: Evidence linking long-term exposure to outdoor air pollution with 
      allergic rhinitis (AR) in children is scare, and the role of components of air 
      pollution and timing of exposure remains unclear. OBJECTIVE: To assess the 
      association of pre- and post-natal exposure to air pollution with life-time 
      prevalence of AR in preschool children. METHODS: We conducted a cohort study of 
      2598 children aged 3-6 years in Changsha, China. The lifetime prevalence of AR 
      was assessed by a questionnaire administered by parents. Children's exposures to 
      dioxide nitrogen (NO(2)), sulfur dioxide (SO(2)) and particulate matter with an 
      aerodynamic diameter </= 10 mum (PM(10)) during different pre- and post-natal timing 
      windows were estimated using the measured concentrations at monitoring stations. 
      The odds ratio (OR) and 95% confidence interval (CI) of childhood AR for exposure 
      to different air pollutants during different timing windows were assessed by 
      logistic regression model in terms of an interquartile range (IQR) increase in 
      exposure level. RESULTS: Life-time prevalence of AR in preschool children (7.3%) 
      was associated with both pre- and post-natal exposure to traffic-related air 
      pollution (TRAP), but only significant during the third trimester of pregnancy 
      with adjusted OR = 1.40 (95% CI: 1.08-1.82) for a 15 mug/m(3) increase in NO(2) 
      and during the first-year of life with adjusted OR = 1.36 (95% CI: 1.03-1.78) and 
      1.54 (95% CI: 1.07-2.21) respectively for 11 and 12 mug/m(3) increase in NO(2) and 
      PM(10). The association of early life exposure to TRAP with childhood AR was 
      robust by adjusting for other air pollutants and timing windows. Sensitivity 
      analysis indicated that the association was higher in the children who are male, 
      young, with genetic predisposition by parental atopy, and living in damp houses. 
      CONCLUSION: Early life exposure to traffic-related air pollutant during pregnancy 
      and first-year of life may contribute to childhood AR.
CI  - Copyright A(c) 2016 Elsevier Ltd. All rights reserved.
FAU - Deng, Qihong
AU  - Deng Q
AD  - School of Energy Science and Engineering, Central South University, Changsha, 
      Hunan, China; XiangYa School of Public Health, Central South University, 
      Changsha, Hunan, China. Electronic address: qhdeng@csu.edu.cn.
FAU - Lu, Chan
AU  - Lu C
AD  - School of Energy Science and Engineering, Central South University, Changsha, 
      Hunan, China.
FAU - Yu, Yichen
AU  - Yu Y
AD  - School of Energy Science and Engineering, Central South University, Changsha, 
      Hunan, China.
FAU - Li, Yuguo
AU  - Li Y
AD  - Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, 
      China.
FAU - Sundell, Jan
AU  - Sundell J
AD  - School of Energy Science and Engineering, Central South University, Changsha, 
      Hunan, China; School of Architecture, Tsinghua University, Beijing, China.
FAU - Norback, Dan
AU  - Norback D
AD  - School of Energy Science and Engineering, Central South University, Changsha, 
      Hunan, China; Department of Medical Sciences, Uppsala University, Uppsala, 
      Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161026
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 0UZA3422Q4 (Sulfur Dioxide)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Air Pollutants/adverse effects/analysis
MH  - Air Pollution/*adverse effects/analysis
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Environmental Exposure/adverse effects/analysis
MH  - Environmental Monitoring/methods
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Motor Vehicles
MH  - Nitrogen Dioxide/adverse effects/analysis
MH  - Particulate Matter/adverse effects/analysis
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/epidemiology/etiology
MH  - Prevalence
MH  - Rhinitis, Allergic/*epidemiology/*etiology
MH  - Sulfur Dioxide/adverse effects/analysis
OTO - NOTNLM
OT  - Air pollution
OT  - Allergic disease
OT  - Children health
OT  - First-year of life
OT  - Pregnancy
OT  - Rhinitis
EDAT- 2016/11/28 06:00
MHDA- 2018/01/09 06:00
CRDT- 2016/11/28 06:00
PHST- 2016/08/03 00:00 [received]
PHST- 2016/10/18 00:00 [revised]
PHST- 2016/10/24 00:00 [accepted]
PHST- 2016/11/28 06:00 [entrez]
PHST- 2016/11/28 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
AID - S0954-6111(16)30279-7 [pii]
AID - 10.1016/j.rmed.2016.10.016 [doi]
PST - ppublish
SO  - Respir Med. 2016 Dec;121:67-73. doi: 10.1016/j.rmed.2016.10.016. Epub 2016 Oct 
      26.