PMID- 27889457
OWN - NLM
STAT- MEDLINE
DCOM- 20170919
LR  - 20190117
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 80
IP  - 1
DP  - 2017 Jan
TI  - A study of oxidative stress and the newer antiepileptic drugs in epilepsy 
      associated with severe motor and intellectual disabilities.
PG  - 19-28
LID - S1726-4901(16)30201-5 [pii]
LID - 10.1016/j.jcma.2016.10.005 [doi]
AB  - BACKGROUND: Patients with severe motor and intellectual disabilities (SMID) are 
      those who have both severe intellectual disabilities and severe physical 
      disabilities. Intractable epilepsy is often associated with SMID. The purpose of 
      this study was to elucidate the relationship between epilepsy associated with 
      SMID and oxidative stress, and to clarify the safety and efficacy of the newer 
      antiepileptic drugs (newer AEDs), lamotrigine and levetiracetam. METHODS: This 
      study was conducted in 27 SMID patients with epilepsy who were treated with the 
      newer AEDs. The patient characteristics and the safety and efficacy of the newer 
      AEDs were investigated. The reactive oxygen metabolite (d-ROM) and biological 
      antioxidant potential (BAP) levels were measured as indicators of the degree of 
      oxidative stress. The relationship between the investigation results (the patient 
      characteristics, and the safety and efficacy of the newer AEDs) and the results 
      of measurements of the d-ROMs/BAP were analyzed. RESULTS: All the patients who 
      discontinued the newer AEDs had abnormal plasma d-ROM levels. In addition, all 
      the patients who developed adverse events also had abnormal d-ROM levels. 
      Furthermore, there was a trend toward a lower response rate in patients with 
      higher plasma d-ROM levels. CONCLUSION: The results of this study suggested that 
      d-ROM levels are useful for predicting the safety and efficacy of the newer AEDs 
      (lamotrigine, levetiracetam) in SMID patients with intractable epilepsy. 
      Therefore, d-ROMs could be important biomarkers for determining the safety and 
      efficacy of drug therapy in SMID patients with epilepsy.
CI  - Copyright (c) 2016. Published by Elsevier Taiwan LLC.
FAU - Morimoto, Masahito
AU  - Morimoto M
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan; Japanese Red Cross Tokushima Hinomine Rehabilitation Center for 
      People with Disabilities, Tokushima, Japan. Electronic address: 
      morimoto@hinomine-mrc.jp.
FAU - Satomura, Shigeko
AU  - Satomura S
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with 
      Disabilities, Tokushima, Japan.
FAU - Hashimoto, Toshiaki
AU  - Hashimoto T
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with 
      Disabilities, Tokushima, Japan.
FAU - Kyotani, Shojiro
AU  - Kyotani S
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161123
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Anticonvulsants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/adverse effects/*therapeutic use
MH  - Child
MH  - Epilepsy/*drug therapy
MH  - Female
MH  - Humans
MH  - Intellectual Disability/complications/*metabolism
MH  - Male
MH  - Motor Neuron Disease/complications/*metabolism
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - antiepileptic drugs
OT  - children with disabilities
OT  - epilepsy
OT  - oxidative stress
EDAT- 2016/11/28 06:00
MHDA- 2017/09/20 06:00
CRDT- 2016/11/28 06:00
PHST- 2016/03/30 00:00 [received]
PHST- 2016/06/13 00:00 [revised]
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/11/28 06:00 [pubmed]
PHST- 2017/09/20 06:00 [medline]
PHST- 2016/11/28 06:00 [entrez]
AID - S1726-4901(16)30201-5 [pii]
AID - 10.1016/j.jcma.2016.10.005 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2017 Jan;80(1):19-28. doi: 10.1016/j.jcma.2016.10.005. Epub 
      2016 Nov 23.