PMID- 27889555
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20171204
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 228
DP  - 2017 Feb 1
TI  - Correlation between microvascular dysfunction and B-type natriuretic peptide 
      levels in non-ischemic heart failure patients with cardiac fibrosis.
PG  - 881-885
LID - S0167-5273(16)33502-1 [pii]
LID - 10.1016/j.ijcard.2016.11.054 [doi]
AB  - BACKGROUNDS: The relationship between microvascular dysfunction and plasma B-type 
      natriuretic peptide (BNP) levels remains unclear in heart failure (HF) patients 
      with cardiac fibrosis. METHODS: This study evaluated 55 consecutive non-ischemic 
      HF patients in an effort to determine the relationship between endothelial 
      independent coronary microvascular dysfunction and plasma BNP levels, as well as 
      whether each measure is correlated with myocardial fibrosis. We evaluated plasma 
      BNP levels in patients with stable HF. We used cardiac catheterization to measure 
      trans-cardiac BNP release levels, measuring from the coronary sinus and the 
      aortic root, and coronary flow reserve (CFR). Patients also underwent cardiac 
      magnetic resonance imaging to evaluate for the presence of late gadolinium 
      enhancement (LGE), as an indicator of cardiac fibrosis. RESULTS: CFR in cardiac 
      catheterization was significantly and inversely correlated with plasma BNP levels 
      (r=0.336, p=0.012) and trans-cardiac BNP release levels (r=0.347, p=0.041). 
      Thirty-three patients were LGE-positive. CFR was significantly correlated with 
      plasma BNP levels in the LGE-positive group (r=0.349, p=0.046), but this 
      correlation was not significant in the LGE-negative group. (r=0.338, p=0.125). 
      Multivariate logistic regression analysis revealed that a plasma BNP levels 
      >180pg/ml at stable HF condition was significant and independent predictor of 
      CFR<2.5 in all patients (p=0.035, odds ratio: 5.2, 95% confidence interval: 
      1.1-29.0), and in the LGE-positive group (p=0.040, odds ratio: 5.4, 95% 
      confidence interval: 1.1-27.2). CONCLUSIONS: In non-ischemic HF patients 
      especially those with cardiac fibrosis, endothelial independent microvascular 
      dysfunction is closely correlated with plasma BNP levels, and ventricular wall 
      tension.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Hirakawa, Kyoko
AU  - Hirakawa K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Yamamuro, Megumi
AU  - Yamamuro M
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan. Electronic address: 
      yamamuro@kumamoto-u.ac.jp.
FAU - Uemura, Tomoaki
AU  - Uemura T
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Takashio, Seiji
AU  - Takashio S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Kaikita, Koichi
AU  - Kaikita K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Utsunomiya, Daisuke
AU  - Utsunomiya D
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, Kumamoto, Japan.
FAU - Nakayama, Mina
AU  - Nakayama M
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Yamamoto, Eiichiro
AU  - Yamamoto E
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Yamashita, Yasuyuki
AU  - Yamashita Y
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, Kumamoto, Japan.
FAU - Hokimoto, Seiji
AU  - Hokimoto S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Tsujita, Kenichi
AU  - Tsujita K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161108
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Catheterization
MH  - Cohort Studies
MH  - Coronary Circulation/physiology
MH  - Endomyocardial Fibrosis/*blood/complications/*physiopathology
MH  - Female
MH  - Heart Failure/*blood/complications/*physiopathology
MH  - Humans
MH  - Male
MH  - Microvessels/*physiopathology
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
OTO - NOTNLM
OT  - B-type natriuretic peptide
OT  - Cardiac fibrosis
OT  - Coronary microvascular dysfunction
OT  - Heart failure
EDAT- 2016/11/28 06:00
MHDA- 2017/12/05 06:00
CRDT- 2016/11/28 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2016/11/05 00:00 [accepted]
PHST- 2016/11/28 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2016/11/28 06:00 [entrez]
AID - S0167-5273(16)33502-1 [pii]
AID - 10.1016/j.ijcard.2016.11.054 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Feb 1;228:881-885. doi: 10.1016/j.ijcard.2016.11.054. Epub 
      2016 Nov 8.