PMID- 27889578
OWN - NLM
STAT- MEDLINE
DCOM- 20170703
LR  - 20220318
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 341
DP  - 2017 Jan 26
TI  - Molecular neurobiology of mTOR.
PG  - 112-153
LID - S0306-4522(16)30638-8 [pii]
LID - 10.1016/j.neuroscience.2016.11.017 [doi]
AB  - Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase 
      that controls several important aspects of mammalian cell function. mTOR activity 
      is modulated by various intra- and extracellular factors; in turn, mTOR changes 
      rates of translation, transcription, protein degradation, cell signaling, 
      metabolism, and cytoskeleton dynamics. mTOR has been repeatedly shown to 
      participate in neuronal development and the proper functioning of mature neurons. 
      Changes in mTOR activity are often observed in nervous system diseases, including 
      genetic diseases (e.g., tuberous sclerosis complex, Pten-related syndromes, 
      neurofibromatosis, and Fragile X syndrome), epilepsy, brain tumors, and 
      neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, and 
      Huntington's disease). Neuroscientists only recently began deciphering the 
      molecular processes that are downstream of mTOR that participate in proper 
      function of the nervous system. As a result, we are gaining knowledge about the 
      ways in which aberrant changes in mTOR activity lead to various nervous system 
      diseases. In this review, we provide a comprehensive view of mTOR in the nervous 
      system, with a special focus on the neuronal functions of mTOR (e.g., control of 
      translation, transcription, and autophagy) that likely underlie the contribution 
      of mTOR to nervous system diseases.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Switon, Katarzyna
AU  - Switon K
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 
      Warsaw 02-109, Poland.
FAU - Kotulska, Katarzyna
AU  - Kotulska K
AD  - Department of Neurology and Epileptology, Children's Memorial Health Institute, 
      Aleja Dzieci Polskich 20, Warsaw 04-730, Poland.
FAU - Janusz-Kaminska, Aleksandra
AU  - Janusz-Kaminska A
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 
      Warsaw 02-109, Poland.
FAU - Zmorzynska, Justyna
AU  - Zmorzynska J
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 
      Warsaw 02-109, Poland.
FAU - Jaworski, Jacek
AU  - Jaworski J
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 
      Warsaw 02-109, Poland. Electronic address: jaworski@iimcb.gov.pl.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161123
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Nervous System/*metabolism
MH  - Nervous System Diseases/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - CNS disease
OT  - mTOR
OT  - neuronal development
OT  - neuronal plasticity
OT  - rapamycin
EDAT- 2016/11/28 06:00
MHDA- 2017/07/04 06:00
CRDT- 2016/11/28 06:00
PHST- 2016/09/14 00:00 [received]
PHST- 2016/11/09 00:00 [revised]
PHST- 2016/11/13 00:00 [accepted]
PHST- 2016/11/28 06:00 [pubmed]
PHST- 2017/07/04 06:00 [medline]
PHST- 2016/11/28 06:00 [entrez]
AID - S0306-4522(16)30638-8 [pii]
AID - 10.1016/j.neuroscience.2016.11.017 [doi]
PST - ppublish
SO  - Neuroscience. 2017 Jan 26;341:112-153. doi: 10.1016/j.neuroscience.2016.11.017. 
      Epub 2016 Nov 23.