PMID- 27889627
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20210507
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 128
IP  - 1
DP  - 2017 Jan
TI  - Subthalamic oscillations and phase amplitude coupling are greater in the more 
      affected hemisphere in Parkinson's disease.
PG  - 128-137
LID - S1388-2457(16)30643-5 [pii]
LID - 10.1016/j.clinph.2016.10.095 [doi]
AB  - OBJECTIVE: Determine the incidence of resting state oscillations in alpha/beta, 
      high frequency (HFO) bands, and their phase amplitude coupling (PAC) in a large 
      cohort in Parkinson's disease (PD). METHODS: Intra-operative local field 
      potentials (LFPs) from subthalamic nucleus (STN) were recorded from 100 PD 
      subjects, data from 74 subjects were included in the analysis. RESULTS: 
      Alpha/beta oscillations were evident in >99%, HFO in 87% and PAC in 98% of cases. 
      Alpha/beta oscillations (P<0.01) and PAC were stronger in the more affected (MA) 
      hemisphere (P=0.03). Alpha/beta oscillations were primarily found in 13-20Hz (low 
      beta). Beta and HFO frequencies with the greatest coupling, were positively 
      correlated (P=0.001). Tremor attenuated alpha (P=0.002) and beta band 
      oscillations (P<0.001). CONCLUSIONS: STN alpha/beta band oscillations and PAC 
      were evident in ⩾98% cases and were greater in MA hemisphere. Resting tremor 
      attenuated underlying alpha/beta band oscillations. SIGNIFICANCE: Beta band LFP 
      power may be used to drive adaptive deep brain stimulation (aDBS), augmented by a 
      kinematic classifier in tremor dominant PD.
CI  - Copyright (c) 2016 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Shreve, Lauren A
AU  - Shreve LA
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Velisar, Anca
AU  - Velisar A
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Malekmohammadi, Mahsa
AU  - Malekmohammadi M
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Koop, Mandy Miller
AU  - Koop MM
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Trager, Megan
AU  - Trager M
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Quinn, Emma J
AU  - Quinn EJ
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Hill, Bruce C
AU  - Hill BC
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Blumenfeld, Zack
AU  - Blumenfeld Z
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA.
FAU - Kilbane, Camilla
AU  - Kilbane C
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA.
FAU - Mantovani, Alessandra
AU  - Mantovani A
AD  - Department of Neurosurgery, Stanford University, Stanford, CA, USA.
FAU - Henderson, Jaimie M
AU  - Henderson JM
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA.
FAU - Bronte-Stewart, Helen
AU  - Bronte-Stewart H
AD  - Department of Neurology and Neurological Sciences, Stanford University, Stanford, 
      CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA. 
      Electronic address: hbs@stanford.edu.
LA  - eng
GR  - R21 NS096398/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20161110
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Aged
MH  - *Alpha Rhythm/physiology
MH  - *Beta Rhythm/physiology
MH  - Cohort Studies
MH  - Deep Brain Stimulation/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/diagnosis/*physiopathology/surgery
MH  - Subthalamic Nucleus/*physiopathology/surgery
OTO - NOTNLM
OT  - Beta oscillations
OT  - Deep brain stimulation
OT  - Parkinson's disease
OT  - Phase amplitude coupling
OT  - Phenotypes
OT  - Tremor
EDAT- 2016/11/28 06:00
MHDA- 2017/06/01 06:00
CRDT- 2016/11/28 06:00
PHST- 2016/05/07 00:00 [received]
PHST- 2016/10/27 00:00 [revised]
PHST- 2016/10/29 00:00 [accepted]
PHST- 2016/11/28 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2016/11/28 06:00 [entrez]
AID - S1388-2457(16)30643-5 [pii]
AID - 10.1016/j.clinph.2016.10.095 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2017 Jan;128(1):128-137. doi: 10.1016/j.clinph.2016.10.095. 
      Epub 2016 Nov 10.