PMID- 27891058
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1179-5557 (Print)
IS  - 1179-5557 (Electronic)
IS  - 1179-5557 (Linking)
VI  - 9
IP  - Suppl 1
DP  - 2016
TI  - IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity.
PG  - 21-28
AB  - Indoleamine 2,3-dioxygenase 2 (IDO2), a homolog of the better-studied 
      tryptophan-catabolizing enzyme IDO1, is an immunomodulatory molecule with 
      potential effects on various diseases including cancer and autoimmunity. Here, we 
      review what is known about the direct connections between IDO2 and immune 
      function, particularly in relationship to autoimmune inflammatory disorders such 
      as rheumatoid arthritis and lupus. Accumulating evidence indicates that IDO2 acts 
      as a pro-inflammatory mediator of autoimmunity, with a functional phenotype 
      distinct from IDO1. IDO2 is expressed in antigen-presenting cells, including B 
      cells and dendritic cells, but affects inflammatory responses in the autoimmune 
      context specifically by acting in B cells to modulate T cell help in multiple 
      model systems. Given that expression of IDO2 can lead to exacerbation of 
      inflammatory responses, IDO2 should be considered a potential therapeutic target 
      for autoimmune disorders.
FAU - Merlo, Lauren M F
AU  - Merlo LM
AD  - Lankenau Institute for Medical Research, Wynnewood, PA, USA.
FAU - Mandik-Nayak, Laura
AU  - Mandik-Nayak L
AD  - Lankenau Institute for Medical Research, Wynnewood, PA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161121
PL  - United States
TA  - Clin Med Insights Pathol
JT  - Clinical medicine insights. Pathology
JID - 101542736
PMC - PMC5119657
OTO - NOTNLM
OT  - 3-dioxygenase 2
OT  - IDO2
OT  - arthritis
OT  - autoimmunity
OT  - indoleamine 2
COIS- Authors disclose no potential conflicts of interest.
EDAT- 2016/11/29 06:00
MHDA- 2016/11/29 06:01
PMCR- 2016/11/21
CRDT- 2016/11/29 06:00
PHST- 2016/07/28 00:00 [received]
PHST- 2016/09/01 00:00 [revised]
PHST- 2016/09/04 00:00 [accepted]
PHST- 2016/11/29 06:00 [entrez]
PHST- 2016/11/29 06:00 [pubmed]
PHST- 2016/11/29 06:01 [medline]
PHST- 2016/11/21 00:00 [pmc-release]
AID - cpath-suppl.1-2016-021 [pii]
AID - 10.4137/CPath.S39930 [doi]
PST - epublish
SO  - Clin Med Insights Pathol. 2016 Nov 21;9(Suppl 1):21-28. doi: 
      10.4137/CPath.S39930. eCollection 2016.