PMID- 27891186
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 8
DP  - 2016
TI  - Relationship between vitamin D status, glycemic control and cardiovascular risk 
      factors in Brazilians with type 2 diabetes mellitus.
PG  - 77
LID - 77
AB  - OBJECTIVES: Determine the prevalence and identify predictors of hypovitaminosis D 
      in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels 
      with variables indicative of glycemic control and cardiovascular risk. RESEARCH 
      DESIGN AND METHODS: We conducted a cross-sectional study with consecutive 
      patients treated at a University Hospital's Endocrinology outpatient clinic 
      located at 12 degrees 58'S latitude, between October 2012 and November 2013. 
      Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL 
      (chemiluminescence). RESULTS: We evaluated 108 patients with mean duration of 
      T2DM of 14.34 +/- 8.05 years and HbA1c of 9.2 +/- 2.1%. Mean age was 
      58.29 +/- 10.34 years. Most were women (72.2%), non-white (89.8%) and had 
      hypertension (75.9%) and dyslipidemia (76.8%). Mean BMI was 28.01 +/- 4.64 kg/m(2); 
      75.9% were overweight. The prevalence of hypovitaminosis D was 62%. In multiple 
      logistic regression, independent predictors of hypovitaminosis D were female 
      gender (OR 3.10, p = 0.02), dyslipidemia (OR 6.50, p < 0.01) and obesity (OR 
      2.55, p = 0.07). In multiple linear regression, only total cholesterol 
      (beta = -0.36, p < 0.01) and BMI (beta = -0.21, p = 0.04) remained associated with 
      levels of 25-hydroxyvitamin D. CONCLUSIONS: Using currently recommended cutoffs, 
      the prevalence of hypovitaminosis D in Brazilians with T2DM was as high as that 
      of non-tropical regions. Female gender, dyslipidemia and obesity were predictors 
      of hypovitaminosis D. Low levels of 25-hydroxyvitamin D were correlated with high 
      cholesterol and BMI values. Future studies are needed to evaluate whether vitamin 
      D replacement would improve these parameters and reduce hard cardiovascular 
      outcomes.
FAU - Rolim, Maria Creusa
AU  - Rolim MC
AUID- ORCID: 0000-0001-9784-7950
AD  - Postgraduate Program in Health Sciences, Federal University of Bahia, Salvador, 
      Bahia Brazil.
FAU - Santos, Barbara Mendes
AU  - Santos BM
AD  - Department of Medicine and Diagnostic Support, Medical School of Bahia, Federal 
      University of Bahia, Salvador, Bahia Brazil.
FAU - Conceicao, Gildasio
AU  - Conceicao G
AD  - Medical Genetics Laboratory, Federal University of Bahia, Salvador, Bahia Brazil.
FAU - Rocha, Paulo Novis
AU  - Rocha PN
AD  - Postgraduate Program in Health Sciences, Federal University of Bahia, Salvador, 
      Bahia Brazil ; Department of Medicine and Diagnostic Support, Medical School of 
      Bahia, Federal University of Bahia, Salvador, Bahia Brazil.
LA  - eng
PT  - Journal Article
DEP - 20161116
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC5112665
OTO - NOTNLM
OT  - Dyslipidemia
OT  - Obesity
OT  - Type 2 diabetes mellitus
OT  - Vitamin D
EDAT- 2016/11/29 06:00
MHDA- 2016/11/29 06:01
PMCR- 2016/11/16
CRDT- 2016/11/29 06:00
PHST- 2016/06/06 00:00 [received]
PHST- 2016/11/04 00:00 [accepted]
PHST- 2016/11/29 06:00 [entrez]
PHST- 2016/11/29 06:00 [pubmed]
PHST- 2016/11/29 06:01 [medline]
PHST- 2016/11/16 00:00 [pmc-release]
AID - 188 [pii]
AID - 10.1186/s13098-016-0188-7 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2016 Nov 16;8:77. doi: 10.1186/s13098-016-0188-7. 
      eCollection 2016.