PMID- 27891379
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 10
IP  - 10
DP  - 2016 Oct
TI  - Rare Occurrence of Drug Induced Subacute Cutaneous Lupus Erythematosus with 
      Leflunomide Therapy.
PG  - OD06-OD07
AB  - Leflunomide is an immunomodulatory drug exhibiting anti-inflammatory, 
      anti-proliferative and immunosuppressive effects. It has been widely used for 
      treatment of active rheumatoid arthritis. Despite its good safety profile 
      cutaneous side effects like alopecia, eczema, pruritis and dry skin have been 
      reported with Leflunomide use. Skin ucleration, vasculitis, lichenoid drug rash 
      and Subacute Cutaneous Lupus Erythematosus (SCLE) have been rarely reported with 
      its use. A rare case of Leflunomide induced SCLE is being reported in a female 
      patient with rheumatoid arthritis. The clinical features, histopathological and 
      immunological characteristics were consistent with drug induced SCLE. Withdrawal 
      of Leflunomide along with short course of topical steroids resulted in resolution 
      of symptoms suggesting the drug to be the culprit. As this drug comes into 
      widespread use, it remains to be seen whether more cases of DI-SCLE will occur/be 
      reported. Fortunately, such a condition till times appears rare and is reversible 
      once the drug is discontinued thus avoiding over evaluation and over treatment if 
      the triggering drug is recognized.
FAU - Singh, Harpreet
AU  - Singh H
AD  - Senior Professor, Department of Medicine, Pt. BD Sharma PGIMS , Rohtak, Haryana, 
      India .
FAU - Sukhija, Gagandeep
AU  - Sukhija G
AD  - Resident, Department of Medicine, Pt. BD Sharma PGIMS , Rohtak, Haryana, India .
FAU - Tanwar, Vikram
AU  - Tanwar V
AD  - Resident, Department of Medicine, Pt. BD Sharma PGIMS , Rohtak, Haryana, India .
FAU - Arora, Sameer
AU  - Arora S
AD  - Resident, Department of Medicine, Pt. BD Sharma PGIMS , Rohtak, Haryana, India .
FAU - Bhutani, Jaikrit
AU  - Bhutani J
AD  - Intern, Department of Medicine, Pt. BD Sharma PGIMS , Rohtak, Haryana, India .
LA  - eng
PT  - Case Reports
DEP - 20161001
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC5121717
OTO - NOTNLM
OT  - DI-SCLE
OT  - Immunomodulatory drug
OT  - Rheumatoid arthritis
EDAT- 2016/11/29 06:00
MHDA- 2016/11/29 06:01
PMCR- 2016/12/01
CRDT- 2016/11/29 06:00
PHST- 2016/02/02 00:00 [received]
PHST- 2016/04/03 00:00 [accepted]
PHST- 2016/11/29 06:00 [entrez]
PHST- 2016/11/29 06:00 [pubmed]
PHST- 2016/11/29 06:01 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2016/14508.8667 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2016 Oct;10(10):OD06-OD07. doi: 10.7860/JCDR/2016/14508.8667. 
      Epub 2016 Oct 1.