PMID- 27892894
OWN - NLM
STAT- MEDLINE
DCOM- 20170728
LR  - 20181202
IS  - 1732-2693 (Electronic)
IS  - 0032-5449 (Linking)
VI  - 70
IP  - 0
DP  - 2016 Oct 14
TI  - Overuse of proton pump inhibitors and its consequences.
PG  - 1112-1116
AB  - Direct inhibition of H+ ion excretion to the gastric lumen makes proton pump 
      inhibitors (PPI) the most effective drugs against gastric acid-related diseases. 
      Over recent years usage of proton pump inhibitors has increased dramatically. Due 
      to the low costs, high efficacy and rarity of adverse effects, their use is 
      prevalent and often it does not correspond with existing medical guidelines. The 
      literature lists stress ulcer prophylaxis among patients with low risk of 
      bleeding, routine 'gastroprotective' medication during treatment and non-specific 
      abdominal symptoms as the most common patterns of off-label PPI use. This article 
      summarizes the influence of PPI therapy on gastric mucosa, absorption and 
      occurrence of adverse effects. The authors note that their low awareness among 
      physicians contributes to wide and imprudent use of drugs of this group.
FAU - Kazberuk, Marcin
AU  - Kazberuk M
AD  - I Klinika Nefrologii i Transplantologii z Osrodkiem Dializ Uniwersytetu 
      Medycznego w Bialymstoku.
FAU - Brzosko, Szymon
AU  - Brzosko S
AD  - I Klinika Nefrologii i Transplantologii z Osrodkiem Dializ Uniwersytetu 
      Medycznego w Bialymstoku.
FAU - Hryszko, Tomasz
AU  - Hryszko T
AD  - I Klinika Nefrologii i Transplantologii z Osrodkiem Dializ Uniwersytetu 
      Medycznego w Bialymstoku.
FAU - Naumnik, Beata
AU  - Naumnik B
AD  - I Klinika Nefrologii i Transplantologii z Osrodkiem Dializ Uniwersytetu 
      Medycznego w Bialymstoku.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161014
PL  - Poland
TA  - Postepy Hig Med Dosw (Online)
JT  - Postepy higieny i medycyny doswiadczalnej (Online)
JID - 101206517
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - Peptic Ulcer/*prevention & control
MH  - Prescription Drug Overuse/*adverse effects
MH  - Proton Pump Inhibitors/*therapeutic use
EDAT- 2016/11/29 06:00
MHDA- 2017/07/29 06:00
CRDT- 2016/11/29 06:00
PHST- 2016/11/29 06:00 [entrez]
PHST- 2016/11/29 06:00 [pubmed]
PHST- 2017/07/29 06:00 [medline]
AID - 1222106 [pii]
AID - 10.5604/17322693.1222106 [doi]
PST - epublish
SO  - Postepy Hig Med Dosw (Online). 2016 Oct 14;70(0):1112-1116. doi: 
      10.5604/17322693.1222106.