PMID- 27893526
OWN - NLM
STAT- MEDLINE
DCOM- 20180912
LR  - 20180912
IS  - 1473-5695 (Electronic)
IS  - 0969-9546 (Linking)
VI  - 25
IP  - 2
DP  - 2018 Apr
TI  - Effect of oxygen therapy on myocardial salvage in ST elevation myocardial 
      infarction: the randomized SOCCER trial.
PG  - 78-84
LID - 10.1097/MEJ.0000000000000431 [doi]
AB  - OBJECTIVE: Recent studies suggest that administration of O2 in patients with 
      acute myocardial infarction may have negative effects. With the use of cardiac 
      MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST 
      elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary 
      intervention (PCI). MATERIALS AND METHODS: This study was a randomized-controlled 
      trial conducted at two university hospitals in Sweden. Normoxic STEMI patients 
      were randomized in the ambulance to either supplemental O2 (10 l/min) or room air 
      until the conclusion of the PCI. CMR was performed 2-6 days after the inclusion. 
      The primary endpoint was the myocardial salvage index assessed by CMR. The 
      secondary endpoints included infarct size and myocardium at risk. RESULTS: At 
      inclusion, the O2 (n=46) and air (n=49) patient groups had similar patient 
      characteristics. There were no significant differences in myocardial salvage 
      index [53.9+/-25.1 vs. 49.3+/-24.0%; 95% confidence interval (CI): -5.4 to 14.6], 
      myocardium at risk (31.9+/-10.0% of the left ventricle in the O2 group vs. 
      30.0+/-11.8% in the air group; 95% CI: -2.6 to 6.3), or infarct size (15.6+/-10.4% of 
      the left ventricle vs. 16.0+/-11.0%; 95% CI: -4.7 to 4.1). CONCLUSION: In STEMI 
      patients undergoing acute PCI, we found no effect of high-flow oxygen compared 
      with room air on the size of ischemia before PCI, myocardial salvage, or the 
      resulting infarct size. These results support the safety of withholding 
      supplemental oxygen in normoxic STEMI patients.
FAU - Khoshnood, Ardavan
AU  - Khoshnood A
AD  - Department of Emergency and Internal Medicine.
FAU - Carlsson, Marcus
AU  - Carlsson M
AD  - Section of Clinical Physiology, Clinical Sciences Lund, Skane University 
      Hospital, Lund University.
FAU - Akbarzadeh, Mahin
AU  - Akbarzadeh M
AD  - Department of Emergency and Internal Medicine.
FAU - Bhiladvala, Pallonji
AU  - Bhiladvala P
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
FAU - Roijer, Anders
AU  - Roijer A
AD  - Department of Cardiology, Skane University Hospital.
FAU - Nordlund, David
AU  - Nordlund D
AD  - Section of Clinical Physiology, Clinical Sciences Lund, Skane University 
      Hospital, Lund University.
FAU - Hoglund, Peter
AU  - Hoglund P
AD  - Region Skane Research and Development Centre.
FAU - Zughaft, David
AU  - Zughaft D
AD  - Department of Cardiology, Skane University Hospital.
FAU - Todorova, Lizbet
AU  - Todorova L
AD  - Region Skane Prehospital Unit, Lund.
FAU - Mokhtari, Arash
AU  - Mokhtari A
AD  - Department of Emergency and Internal Medicine.
FAU - Arheden, Hakan
AU  - Arheden H
AD  - Section of Clinical Physiology, Clinical Sciences Lund, Skane University 
      Hospital, Lund University.
FAU - Erlinge, David
AU  - Erlinge D
AD  - Department of Cardiology, Skane University Hospital.
FAU - Ekelund, Ulf
AU  - Ekelund U
AD  - Department of Emergency and Internal Medicine.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Emerg Med
JT  - European journal of emergency medicine : official journal of the European Society 
      for Emergency Medicine
JID - 9442482
SB  - IM
MH  - Adult
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Oxygen Inhalation Therapy/*methods
MH  - Percutaneous Coronary Intervention/methods
MH  - ST Elevation Myocardial Infarction/*diagnostic imaging/physiopathology/*therapy
MH  - Treatment Outcome
EDAT- 2016/11/29 06:00
MHDA- 2018/09/13 06:00
CRDT- 2016/11/29 06:00
PHST- 2016/11/29 06:00 [pubmed]
PHST- 2018/09/13 06:00 [medline]
PHST- 2016/11/29 06:00 [entrez]
AID - 10.1097/MEJ.0000000000000431 [doi]
PST - ppublish
SO  - Eur J Emerg Med. 2018 Apr;25(2):78-84. doi: 10.1097/MEJ.0000000000000431.