PMID- 27893563
OWN - NLM
STAT- MEDLINE
DCOM- 20190212
LR  - 20190215
IS  - 2152-0895 (Electronic)
IS  - 1539-8412 (Linking)
VI  - 41
IP  - 2
DP  - 2018 Apr/Jun
TI  - Resistance Training Improves Muscle Function and Cardiometabolic Risks But Not 
      Quality of Life in Older People With Type 2 Diabetes Mellitus: A Randomized 
      Controlled Trial.
PG  - 65-76
LID - 10.1519/JPT.0000000000000107 [doi]
AB  - BACKGROUND AND PURPOSE: In older people with type 2 diabetes mellitus (T2DM), the 
      effects of aging and T2DM may compromise the function of skeletal muscle, 
      deteriorate metabolic status, and jeopardize physical performance, aerobic 
      capacity, and quality of life (QoL). The purpose of this study was to investigate 
      the effects of 12 weeks of resistance training (RT) on muscle function, physical 
      performance, cardiometabolic risks, and QoL in older people with T2DM. METHODS: 
      This study was a randomized controlled trial that employed block randomization, 
      assessor blinding, and the intention-to-treat principle. Thirty people 65 years 
      or older with a diagnosis of T2DM were randomly assigned to either an exercise 
      group or a control group and were further stratified by gender. The exercise 
      group performed 8 RT exercises in 3 sets of 8 to 12 repetitions at 75% 
      1-repetition maximum (1-RM) 3 times per week for 12 weeks. The control group 
      received usual care and maintained their daily activities and lifestyle. Muscle 
      function (1-RM and muscle oxygenation responses), physical performance 
      (5-repetition sit-to-stand test and Timed Up and Go test), cardiometabolic risks 
      (aerobic capacity, blood pressure, body composition, glycemic control, lipids 
      levels, and high-sensitivity C-reactive protein levels), and QoL (Audit of 
      Diabetes-Dependent Quality of Life 19) were assessed at baseline (week 0) and 
      after the 12-week interventions (week 12). RESULTS: The 1-RM chest-press and 
      leg-press strength and physical performance in 5-repetition sit-to-stand test 
      were significantly improved in the exercise group compared with the controls 
      after the interventions. The exercise group had significantly lower resting 
      systolic blood pressure (by -12.1 mm Hg, P = 0.036) than did the controls after 
      12 weeks of RT, without any significant within-group change in either group after 
      intervention. The waist circumference, fasting glucose levels, and peak diastolic 
      blood pressure tended to favor RT over usual care after the interventions. 
      CONCLUSION: Twelve weeks of RT increased the maximal strength in chest-press and 
      leg-press tests, and improved 5-repetition sit-to-stand performance in older 
      people with T2DM. Our study demonstrated that supervised, structured RT was able 
      to promote muscle function and alleviate cardiometabolic risks in people with 
      T2DM 65 years or older.
FAU - Hsieh, Ping-Lun
AU  - Hsieh PL
AD  - School and Graduate Institute of Physical Therapy, College of Medicine, National 
      Taiwan University, Taipei, Taiwan.
AD  - Department of Rehabilitation, Keelung Hospital, Ministry of Health and Welfare, 
      Keelung, Taiwan.
FAU - Tseng, Chin-Hsiao
AU  - Tseng CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei, Taiwan.
FAU - Tseng, Yufeng Jane
AU  - Tseng YJ
AD  - The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - Department of Computer Science and Information Engineering, National Taiwan 
      University, Taipei, Taiwan.
AD  - Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan 
      University, Taipei, Taiwan.
FAU - Yang, Wei-Shiung
AU  - Yang WS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei, Taiwan.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - Center for Obesity, Lifestyle and Metabolic Surgery, National Taiwan University 
      Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Geriatr Phys Ther
JT  - Journal of geriatric physical therapy (2001)
JID - 101142169
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Body Composition
MH  - Diabetes Mellitus, Type 2/metabolism/physiopathology/*rehabilitation
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle Strength/*physiology
MH  - Muscle, Skeletal/physiology
MH  - *Quality of Life
MH  - *Resistance Training
EDAT- 2016/11/29 06:00
MHDA- 2019/02/13 06:00
CRDT- 2016/11/29 06:00
PHST- 2016/11/29 06:00 [pubmed]
PHST- 2019/02/13 06:00 [medline]
PHST- 2016/11/29 06:00 [entrez]
AID - 10.1519/JPT.0000000000000107 [doi]
PST - ppublish
SO  - J Geriatr Phys Ther. 2018 Apr/Jun;41(2):65-76. doi: 10.1519/JPT.0000000000000107.