PMID- 27895278
OWN - NLM
STAT- MEDLINE
DCOM- 20170522
LR  - 20181113
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 96
IP  - 2
DP  - 2017 Feb 8
TI  - Paracoccidioidomycosis in Brazilian Patients With and Without Human 
      Immunodeficiency Virus Infection.
PG  - 368-372
LID - 10.4269/ajtmh.16-0254 [doi]
AB  - Paracoccidioidomycosis (PCM) is endemic to Latin America, where 10 million people 
      may be infected with Paracoccidioides brasiliensis/Paracoccidioides lutzii and 
      1,600,000 individuals live with human immunodeficiency virus (HIV) infection. An 
      epidemiological overlapping of these infections occurred early in acquired 
      immunodeficiency syndrome era with nearly 180 published cases. This study 
      presents epidemiological, clinical, and outcome profiles for 31 PCM patients with 
      HIV infection diagnosed in a teaching hospital in Brazil, and includes an update 
      of previously reported cases. Medical records were reviewed and data compared 
      with 64 PCM patients without HIV infection. Of the 31 PCM patients with HIV 
      infection, 23 (74.1%) were male, with a median age of 36.7 years, whereas of the 
      64 PCM, 45 (70.3%) were male, with a median age of 35.1 years. Both groups 
      presented similar proportions for smoking and alcoholism. PCM patients with HIV 
      infection presented more fever, weight loss, and the acute clinical form than the 
      PCM patients who had more mucosal and respiratory involvement characterizing the 
      chronic form. Most PCM patients with HIV infection exhibited overlapping symptoms 
      from both clinical forms with median symptom duration of 4.5 months compared with 
      8.3 months for the PCM control. Patients received sulfonamides and/or 
      itraconazole for a median of 15.7 and 16.7 months for PCM/HIV-infected and PCM, 
      respectively. Relapses occurred more in PCM (12 [30%]) than PCM/HIV-infected (4 
      [14.8%]) patients, whose mortality rate was higher (10 [32.8%]) than PCM patients 
      (8 [20%]). The cases of PCM/HIV infection confirm that HIV can interact with some 
      endemic diseases without increasing their frequency, while changing their natural 
      history, clinical presentation, and outcome. The data presented here are in 
      agreement with those observed in other studies.
CI  - (c) The American Society of Tropical Medicine and Hygiene.
FAU - Almeida, Fabricio Arantes de
AU  - Almeida FA
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Neves, Fernando Freitas
AU  - Neves FF
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Mora, Delio Jose
AU  - Mora DJ
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Reis, Tarcisio Albertin Dos
AU  - Reis TA
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Sotini, Diego Moelas
AU  - Sotini DM
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Ribeiro, Barbara De Melo
AU  - Ribeiro BM
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Andrade-Silva, Leonardo Euripedes
AU  - Andrade-Silva LE
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Nascentes, Gabriel Nogueira
AU  - Nascentes GN
AD  - Federal Institute of Triangulo Mineiro, Uberaba, Brazil.
FAU - Ferreira-Paim, Kennio
AU  - Ferreira-Paim K
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil.
FAU - Silva-Vergara, Mario Leon
AU  - Silva-Vergara ML
AD  - Infectious Diseases Unit, Internal Medicine Department, Triangulo Mineiro Federal 
      University, Uberaba, Brazil. marioleon.dip@mednet.com.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161128
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - IM
MH  - Adult
MH  - Brazil/epidemiology
MH  - Coinfection/*microbiology
MH  - Female
MH  - HIV Infections/*complications/diagnosis/epidemiology/microbiology
MH  - Humans
MH  - Male
MH  - Paracoccidioidomycosis/*complications/diagnosis/epidemiology
MH  - Treatment Outcome
PMC - PMC5303038
EDAT- 2016/11/30 06:00
MHDA- 2017/05/23 06:00
PMCR- 2018/02/08
CRDT- 2016/11/30 06:00
PHST- 2016/04/01 00:00 [received]
PHST- 2016/10/26 00:00 [accepted]
PHST- 2016/11/30 06:00 [pubmed]
PHST- 2017/05/23 06:00 [medline]
PHST- 2016/11/30 06:00 [entrez]
PHST- 2018/02/08 00:00 [pmc-release]
AID - ajtmh.16-0254 [pii]
AID - 10.4269/ajtmh.16-0254 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Feb 8;96(2):368-372. doi: 10.4269/ajtmh.16-0254. Epub 
      2016 Nov 28.