PMID- 27895696
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2016
DP  - 2016
TI  - Efficacy of Danlou Tablet in Patients with Non-ST Elevation Acute Coronary 
      Syndrome Undergoing Percutaneous Coronary Intervention: Results from a 
      Multicentre, Placebo-Controlled, Randomized Trial.
PG  - 7960503
LID - 7960503
AB  - This study seeks to investigate potential cardioprotection of Danlou Tablets in 
      patients undergoing PCI with non-ST elevation acute coronary syndrome (NSTE-ACS). 
      219 patients with NSTE-ACS were randomised to Danlou Tablet pretreatment (n = 
      109) or placebo (n = 110). No patients received statins prior to PCI and all 
      patients were given atorvastatin (10 mg/day) after procedure. The main endpoint 
      was the composite incidence of major adverse cardiac events (MACEs) within 30 
      days after PCI. The proportion of patients with elevated levels of cTn I>5 x 99% 
      of upper reference limit was significantly lower in the Danlou Tablet group at 
      8 h (22.0% versus 34.5%, p = 0.04) and 24 h (23.9% versus 38.2%, p = 0.02) after 
      PCI. The 30-day MACEs occurred in 22.0% of the Danlou Tablet group and 33.6% in 
      the placebo group (p = 0.06). The incidence of MACE at 90-day follow-up was 
      significantly decreased in the Danlou Tablet group compared to the placebo group 
      (23.9% versus 37.3%, p = 0.03). The difference between the groups at 90 days was 
      the incidence of nonfatal myocardial infarction (22% versus 34.5%, p = 0.04). 
      These findings might support that treatment with Danlou Tablet could reduce the 
      incidence of periprocedural myocardial infarction in patients with ACS undergoing 
      PCI.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, 
      Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
FAU - Zhao, Xujie
AU  - Zhao X
AD  - Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, 
      Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
FAU - Mao, Shuai
AU  - Mao S
AD  - Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, 
      Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
FAU - Liu, Shaonan
AU  - Liu S
AUID- ORCID: 0000-0003-4618-5779
AD  - China-Australia International Research Centre for Chinese Medicine (CAIRC-CM), 
      Guangdong Provincial Academy of Traditional Chinese Medicine, Guangzhou 510120, 
      China.
FAU - Guo, Xinfeng
AU  - Guo X
AUID- ORCID: 0000-0003-2699-9740
AD  - China-Australia International Research Centre for Chinese Medicine (CAIRC-CM), 
      Guangdong Provincial Academy of Traditional Chinese Medicine, Guangzhou 510120, 
      China.
FAU - Guo, Liheng
AU  - Guo L
AD  - Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, 
      Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
FAU - Du, Tinghai
AU  - Du T
AD  - Department of Cardiovascular Medicine, First Affiliated Hospital of Henan College 
      of TCM, Zhengzhou 450004, China.
FAU - Yang, Haiyu
AU  - Yang H
AD  - Department of Cardiovascular Medicine, Wuyi Hospital of TCM of Jiangmen City, 
      Jiangmen 529000, China.
FAU - Zhao, Fuhai
AU  - Zhao F
AD  - Department of Cardiology, Xiyuan Hospital, Chinese Academy of Traditional Chinese 
      Medicine, Beijing 100091, China.
FAU - Wu, Keng
AU  - Wu K
AD  - Department of Cardiology, Affiliated Hospital of Guangdong Medical College, 
      Zhanjiang 524023, China.
FAU - Cong, Hongliang
AU  - Cong H
AD  - Department of Cardiology, Tianjin Chest Hospital, Tianjin 300051, China.
FAU - Wu, Yang
AU  - Wu Y
AD  - Department of Cardiovascular Medicine, Oriental Hospital, Beijing University of 
      Traditional Chinese Medicine, Beijing 100078, China.
FAU - Yang, Phillip C
AU  - Yang PC
AUID- ORCID: 0000-0002-6274-895X
AD  - Department of Cardiovascular Medicine, Stanford University School of Medicine, 
      Stanford, CA 94305, USA.
FAU - Chen, Keji
AU  - Chen K
AD  - Department of Cardiology, Xiyuan Hospital, Chinese Academy of Traditional Chinese 
      Medicine, Beijing 100091, China.
FAU - Zhang, Minzhou
AU  - Zhang M
AUID- ORCID: 0000-0002-5657-7891
AD  - Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, 
      Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
LA  - eng
PT  - Journal Article
DEP - 20161108
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5118548
COIS- The authors declare that they have no conflict of interests.
EDAT- 2016/11/30 06:00
MHDA- 2016/11/30 06:01
PMCR- 2016/11/08
CRDT- 2016/11/30 06:00
PHST- 2016/06/15 00:00 [received]
PHST- 2016/09/10 00:00 [revised]
PHST- 2016/10/05 00:00 [accepted]
PHST- 2016/11/30 06:00 [entrez]
PHST- 2016/11/30 06:00 [pubmed]
PHST- 2016/11/30 06:01 [medline]
PHST- 2016/11/08 00:00 [pmc-release]
AID - 10.1155/2016/7960503 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2016;2016:7960503. doi: 10.1155/2016/7960503. 
      Epub 2016 Nov 8.