PMID- 27895986
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 7
IP  - 11
DP  - 2016 Nov 1
TI  - Combined frequency domain photoacoustic and ultrasound imaging for intravascular 
      applications.
PG  - 4441-4449
AB  - Intravascular photoacoustic (IVPA) imaging has the potential to characterize 
      lipid-rich structures based on the optical absorption contrast of tissues. In 
      this study, we explore frequency domain photoacoustics (FDPA) for intravascular 
      applications. The system employed an intensity-modulated continuous wave (CW) 
      laser diode, delivering 1W over an intensity modulated chirp frequency of 
      4-12MHz. We demonstrated the feasibility of this approach on an agar vessel 
      phantom with graphite and lipid targets, imaged using a planar acoustic 
      transducer co-aligned with an optical fibre, allowing for the co-registration of 
      IVUS and FDPA images. A frequency domain correlation method was used for signal 
      processing and image reconstruction. The graphite and lipid targets show an 
      increase in FDPA signal as compared to the background of 21dB and 16dB, 
      respectively. Use of compact CW laser diodes may provide a valuable alternative 
      for the development of photoacoustic intravascular devices instead of pulsed 
      laser systems.
FAU - Castelino, Robin F
AU  - Castelino RF
AD  - Medical Biophysics, University of Toronto, 5 King's College Road, Toronto, ON M5S 
      3G8, Canada; Imaging Research, Sunnybrook Research Institute, 2075 Bayview 
      Avenue, Toronto, Ontario M4N 3M5, Canada.
FAU - Hynes, Michael
AU  - Hynes M
AD  - Imaging Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, 
      Ontario M4N 3M5, Canada.
FAU - Munding, Chelsea E
AU  - Munding CE
AD  - Medical Biophysics, University of Toronto, 5 King's College Road, Toronto, ON M5S 
      3G8, Canada; Imaging Research, Sunnybrook Research Institute, 2075 Bayview 
      Avenue, Toronto, Ontario M4N 3M5, Canada.
FAU - Telenkov, Sergey
AU  - Telenkov S
AD  - PHAST Imaging, 1B Richview Road, Toronto, ON M9A 4M6, Canada.
FAU - Foster, F Stuart
AU  - Foster FS
AD  - Medical Biophysics, University of Toronto, 5 King's College Road, Toronto, ON M5S 
      3G8, Canada; Imaging Research, Sunnybrook Research Institute, 2075 Bayview 
      Avenue, Toronto, Ontario M4N 3M5, Canada.
LA  - eng
PT  - Journal Article
DEP - 20161006
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC5119586
OTO - NOTNLM
OT  - (170.5120) Photoacoustic imaging
OT  - (170.7170) Ultrasound
EDAT- 2016/11/30 06:00
MHDA- 2016/11/30 06:01
PMCR- 2016/10/06
CRDT- 2016/11/30 06:00
PHST- 2016/07/18 00:00 [received]
PHST- 2016/09/27 00:00 [revised]
PHST- 2016/09/30 00:00 [accepted]
PHST- 2016/11/30 06:00 [entrez]
PHST- 2016/11/30 06:00 [pubmed]
PHST- 2016/11/30 06:01 [medline]
PHST- 2016/10/06 00:00 [pmc-release]
AID - 270504 [pii]
AID - 10.1364/BOE.7.004441 [doi]
PST - epublish
SO  - Biomed Opt Express. 2016 Oct 6;7(11):4441-4449. doi: 10.1364/BOE.7.004441. 
      eCollection 2016 Nov 1.