PMID- 27896619
OWN - NLM
STAT- MEDLINE
DCOM- 20170523
LR  - 20221207
IS  - 2095-0225 (Electronic)
IS  - 2095-0217 (Linking)
VI  - 10
IP  - 4
DP  - 2016 Dec
TI  - DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in 
      southern Han Chinese.
PG  - 507-516
LID - 10.1007/s11684-016-0475-6 [doi]
AB  - Immunoglobulin A nephropathy (IgAN) is a common form of chronic 
      glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown 
      the ethnic-specific association between certain human leukocyte antigen (HLA) 
      alleles and IgAN susceptibility. This study was designed to explore the 
      relationship between HLA-DQB1 alleles and disease susceptibility and clinical 
      manifestations of patients with IgAN in southern Han Chinese. A PCR 
      sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN 
      patients and 229 healthy subjects. Clinical data were collected from each patient 
      at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN 
      patients and healthy subjects. High frequency of HLA-DQB1* 060101 and low 
      frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy 
      controls. Further stratification analysis revealed that the frequency of 
      DQB1*060101 was significantly higher in patients with urine protein >/= 1.0 g/24 h 
      than in patients with urine protein < 1.0 g/24 h. In combination with our 
      previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes 
      with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was 
      significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of 
      HLA-DRB1*070101-DQB1*020101 was significantly lower (OR = 0.194, Pc = 0.016) 
      compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles 
      may be a potential predictor of high-risk IgAN susceptibility in Chinese Han 
      population.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, 510080, China.
AD  - Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, 
      Guangzhou, 510080, China.
AD  - Department of Nephrology, Sichuan Provincial People's Hospital, Chengdu, 610072, 
      China.
FAU - Li, Ming
AU  - Li M
AD  - Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, 510080, China.
AD  - Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, 
      Guangzhou, 510080, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Nephrology, Sichuan Provincial People's Hospital, Chengdu, 610072, 
      China.
FAU - Yu, Xueqing
AU  - Yu X
AD  - Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, 510080, China. yuxq@mail.sysu.edu.cn.
AD  - Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, 
      Guangzhou, 510080, China. yuxq@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20161223
PL  - China
TA  - Front Med
JT  - Frontiers of medicine
JID - 101549428
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Glomerulonephritis, IGA/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - DQB1
OT  - IgA nephropathy
OT  - association study
OT  - haplotype
OT  - human leukocyte antigen (HLA)
EDAT- 2016/11/30 06:00
MHDA- 2017/05/24 06:00
CRDT- 2016/11/30 06:00
PHST- 2015/10/11 00:00 [received]
PHST- 2016/07/19 00:00 [accepted]
PHST- 2016/11/30 06:00 [pubmed]
PHST- 2017/05/24 06:00 [medline]
PHST- 2016/11/30 06:00 [entrez]
AID - 10.1007/s11684-016-0475-6 [pii]
AID - 10.1007/s11684-016-0475-6 [doi]
PST - ppublish
SO  - Front Med. 2016 Dec;10(4):507-516. doi: 10.1007/s11684-016-0475-6. Epub 2016 Dec 
      23.