PMID- 2789717
OWN - NLM
STAT- MEDLINE
DCOM- 19891120
LR  - 20190912
IS  - 0268-8697 (Print)
IS  - 0268-8697 (Linking)
VI  - 3
IP  - 1
DP  - 1989
TI  - Differentiation in medulloblastomas and other primitive neuroectodermal tumours.
PG  - 89-100
AB  - Fifty-four cases of primitive neuroectodermal tumour (PNET) including 47 
      medulloblastomas, were examined for evidence of neuronal and glial 
      differentiation, using antibodies to neuron-specific enolase (NSE), neurofilament 
      protein (NF), and glial fibrillary acidic protein (GFAP). In 30 of the cases, 
      antibodies to vimentin, alphafetoprotein, cytokeratin, epithelial membrane 
      antigen and lymphoid markers were also used. Most of the 47 medulloblastomas in 
      the group were NSE positive but NF negative; about half were GFAP positive and 
      three of them were positive for both neuronal markers and for GFAP. Vimentin was 
      demonstrated in four cases and was not always co-expressed with GFAP. 
      Medulloblastomas were negative for all the other markers. Supratentorial PNETs 
      were sometimes positive with neuronal markers but were GFAP negative. The cell 
      specificity of these markers and the interpretation of immunocytochemical 
      findings are discussed in relation to differentiation potential in primitive 
      neuroectodermal tumours.
FAU - Sime, P J
AU  - Sime PJ
AD  - Department of Pathology, University of Edinburgh, Scotland, United Kingdom.
FAU - Gordon, A
AU  - Gordon A
FAU - Hooper, M L
AU  - Hooper ML
FAU - Bell, J E
AU  - Bell JE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Brain Neoplasms/metabolism/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Humans
MH  - Infant
MH  - Male
MH  - Medulloblastoma/metabolism/*pathology
MH  - Middle Aged
MH  - Phosphopyruvate Hydratase/metabolism
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.3109/02688698909001030 [doi]
PST - ppublish
SO  - Br J Neurosurg. 1989;3(1):89-100. doi: 10.3109/02688698909001030.