PMID- 27898192
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20191210
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 39
IP  - 3
DP  - 2017 Mar
TI  - Reappraising hyalinizing clear cell carcinoma: A population-based study with 
      molecular confirmation.
PG  - 503-511
LID - 10.1002/hed.24637 [doi]
AB  - BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) is a rare malignancy, 
      characterized by EWSR1-ATF1 gene fusion, whose behavior is poorly understood, as 
      it was for many years considered a diagnosis of exclusion. METHODS: All available 
      salivary gland carcinomas (n = 594) from our institution were reviewed. Diagnosis 
      of HCCC was confirmed by fluorescence in situ hybridization (FISH) for EWSR1. 
      Literature review was performed. RESULTS: We found 15 patients with HCCCs (10 
      women, 5 men), 13 with EWSR1 rearrangement. Median age at diagnosis was 57 years 
      (range, 31-87 years). Oral cavity (n = 9) and base of tongue (n = 4) were the 
      most frequent primary sites. Combining our cases with those identified in 
      literature review, the 10-year risk of local recurrence and locoregional nodal 
      metastasis were 49% and 15%, respectively. CONCLUSION: Molecularly confirmed HCCC 
      accounted for 2.5% of salivary gland malignancies at our institution. HCCCs are 
      indolent tumors with a propensity for locoregional recurrence. (c) 2016 Wiley 
      Periodicals, Inc. Head Neck 39: 503-511, 2017.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Hernandez-Prera, Juan C
AU  - Hernandez-Prera JC
AD  - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New 
      York.
FAU - Kwan, Ricky
AU  - Kwan R
AD  - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New 
      York.
FAU - Tripodi, Joseph
AU  - Tripodi J
AD  - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New 
      York.
FAU - Chiosea, Simion
AU  - Chiosea S
AD  - Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Cordon-Cardo, Carlos
AU  - Cordon-Cardo C
AD  - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New 
      York.
FAU - Najfeld, Vesna
AU  - Najfeld V
AD  - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New 
      York.
FAU - Demicco, Elizabeth G
AU  - Demicco EG
AD  - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New 
      York.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20161129
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (ATF1 protein, human)
RN  - 0 (Activating Transcription Factor 1)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Activating Transcription Factor 1/*genetics
MH  - Adenocarcinoma, Clear Cell/diagnostic imaging/*genetics/pathology/therapy
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy, Needle
MH  - Carcinoma, Squamous Cell/diagnostic imaging/*genetics/pathology/therapy
MH  - Databases, Factual
MH  - Disease-Free Survival
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - RNA-Binding Protein EWS/*genetics
MH  - RNA-Binding Proteins/genetics
MH  - Retrospective Studies
MH  - Salivary Gland Neoplasms/diagnostic imaging/*genetics/pathology/therapy
MH  - Survival Rate
OTO - NOTNLM
OT  - EWSR1
OT  - clear cell carcinoma
OT  - hyalinizing clear cell carcinoma
OT  - salivary gland
EDAT- 2016/11/30 06:00
MHDA- 2018/03/06 06:00
CRDT- 2016/11/30 06:00
PHST- 2016/02/09 00:00 [received]
PHST- 2016/08/01 00:00 [revised]
PHST- 2016/10/12 00:00 [accepted]
PHST- 2016/11/30 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2016/11/30 06:00 [entrez]
AID - 10.1002/hed.24637 [doi]
PST - ppublish
SO  - Head Neck. 2017 Mar;39(3):503-511. doi: 10.1002/hed.24637. Epub 2016 Nov 29.