PMID- 27898459
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20220318
IS  - 1536-5409 (Electronic)
IS  - 0749-8047 (Print)
IS  - 0749-8047 (Linking)
VI  - 33
IP  - 8
DP  - 2017 Aug
TI  - Characterization of the Adverse Effects Induced by Acetaminophen and Nonsteroidal 
      Anti-Inflammatory Drugs Based on the Analysis of the Japanese Adverse Drug Event 
      Report Database.
PG  - 667-675
LID - 10.1097/AJP.0000000000000457 [doi]
AB  - OBJECTIVES: Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are 
      antipyretic analgesics with established adverse effects (AEs); however, only a 
      few studies have compared their AEs simultaneously. We aimed to compare the AEs 
      of these medications to confirm the respective frequencies of both rare and major 
      AEs. METHODS: We used a high-quality database for spontaneous adverse drug event 
      reporting in Japan. Data were extracted regarding the AEs of acetaminophen and 
      NSAIDs to compare the tendency of the appearance of those AEs between the drugs. 
      We also performed a principal component analysis using the AE data to assess the 
      characteristics of major AEs. RESULTS: Cutaneous disorders and hepatic disorders 
      were the most common AEs induced by acetaminophen and NSAIDs, with 
      gastrointestinal tract disorders also common with NSAID use. Principal component 
      analysis quantitatively showed the tendencies of specific AEs, and it helped 
      demonstrate the characteristics of AEs. Acetaminophen and NSAIDs showed different 
      tendencies in the occurrence of AEs. Each NSAID was plotted based on the tendency 
      of the appearance of major AEs, and AEs were classified by their likelihood of 
      being pharmacological or idiosyncratic. CONCLUSIONS: These findings may help 
      clinicians select an appropriate drug for patients considering their backgrounds, 
      instead of choosing merely based on the class of the drug, for example, 
      cyclooxygenase selectivity. This selection, based on the characteristic 
      information on AEs occurring in clinical settings, might be more suitable for 
      patients.
FAU - Nagai, Junko
AU  - Nagai J
AD  - Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Tokyo, 
      Japan.
FAU - Uesawa, Yoshihiro
AU  - Uesawa Y
FAU - Shimamura, Ryotaro
AU  - Shimamura R
FAU - Kagaya, Hajime
AU  - Kagaya H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Clin J Pain
JT  - The Clinical journal of pain
JID - 8507389
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*adverse effects/therapeutic use
MH  - Analgesics, Non-Narcotic/*adverse effects/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects/therapeutic use
MH  - Databases, Pharmaceutical
MH  - Humans
MH  - Japan
MH  - Principal Component Analysis
PMC - PMC5497783
EDAT- 2016/11/30 06:00
MHDA- 2018/04/04 06:00
PMCR- 2017/07/05
CRDT- 2016/11/30 06:00
PHST- 2016/11/30 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2016/11/30 06:00 [entrez]
PHST- 2017/07/05 00:00 [pmc-release]
AID - 10.1097/AJP.0000000000000457 [doi]
PST - ppublish
SO  - Clin J Pain. 2017 Aug;33(8):667-675. doi: 10.1097/AJP.0000000000000457.