PMID- 27899689
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20220408
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 31
IP  - 2
DP  - 2017 Feb
TI  - Herbal medicine for management of the behavioural and psychological symptoms of 
      dementia (BPSD): A systematic review and meta-analysis.
PG  - 169-183
LID - 10.1177/0269881116675515 [doi]
AB  - Management of the behavioural and psychological symptoms of dementia remains a 
      challenge worldwide. Herbal medicines may play a role in the development of new 
      interventions. To determine effects of herbal medicines for management of the 
      behavioural and psychological symptoms of dementia, meta-analysis was conducted 
      of 31 controlled trials (3613 participants). Frequently tested herbal medicines 
      were the Ginkgo biloba leaf extract EGb 761 (seven studies) and the 
      multi-ingredient formula Yokukansan (eight studies). Sixteen studies tested other 
      herbal medicines. Improvements were detected in Neuropsychiatric Inventory scores 
      in EGb 761 groups compared to placebo (MD -3.46 [-5.94, -0.98]; I(2) = 93%; n = 
      1757) and Yokukansan groups compared to no treatment (SMD -0.53 [-0.86, -0.21]; 
      I(2) = 0%; n = 150). Cognitive scores were improved in EGb 761 groups while 
      Yokukansan did not appear to affect cognitive function. Of the other herbal 
      medicines, there were improvements in the behavioural and psychological symptoms 
      of dementia and cognitive outcomes in two of four placebo-controlled studies. EGb 
      761 and Yokukansan appeared safe and well tolerated. Adverse effects and dropouts 
      were not reported consistently for the other herbal medicines. Weaknesses of 
      these included short durations, small sample sizes, lack of blinding and other 
      risks of bias. Well-designed studies are needed to further investigate the 
      reported effects of these interventions on the behavioural and psychological 
      symptoms of dementia.
FAU - Hyde, Anna J
AU  - Hyde AJ
AD  - 1 The China-Australia International Research Centre for Chinese Medicine, School 
      of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
FAU - May, Brian H
AU  - May BH
AD  - 1 The China-Australia International Research Centre for Chinese Medicine, School 
      of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
FAU - Dong, Lin
AU  - Dong L
AD  - 1 The China-Australia International Research Centre for Chinese Medicine, School 
      of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
FAU - Feng, Mei
AU  - Feng M
AD  - 2 Guangdong Provincial Academy of Chinese Medical Sciences & Guangdong Provincial 
      Hospital of Chinese Medicine, Guangzhou, China.
FAU - Liu, Shaonan
AU  - Liu S
AD  - 2 Guangdong Provincial Academy of Chinese Medical Sciences & Guangdong Provincial 
      Hospital of Chinese Medicine, Guangzhou, China.
FAU - Guo, Xinfeng
AU  - Guo X
AD  - 2 Guangdong Provincial Academy of Chinese Medical Sciences & Guangdong Provincial 
      Hospital of Chinese Medicine, Guangzhou, China.
FAU - Zhang, Anthony Lin
AU  - Zhang AL
AD  - 1 The China-Australia International Research Centre for Chinese Medicine, School 
      of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
FAU - Lu, Chuanjian
AU  - Lu C
AD  - 2 Guangdong Provincial Academy of Chinese Medical Sciences & Guangdong Provincial 
      Hospital of Chinese Medicine, Guangzhou, China.
FAU - Xue, Charlie Changli
AU  - Xue CC
AD  - 1 The China-Australia International Research Centre for Chinese Medicine, School 
      of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
AD  - 2 Guangdong Provincial Academy of Chinese Medical Sciences & Guangdong Provincial 
      Hospital of Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20161207
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Behavior/*drug effects
MH  - Cognition/*drug effects
MH  - Dementia/*drug therapy
MH  - Herbal Medicine/methods
MH  - Humans
MH  - Neuropsychological Tests
MH  - Phytotherapy/methods
MH  - Plant Extracts/*therapeutic use
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Dementia
OT  - herbal medicine
OT  - neurocognitive disorders
OT  - systematic review
EDAT- 2016/12/03 06:00
MHDA- 2018/01/05 06:00
CRDT- 2016/12/01 06:00
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
PHST- 2016/12/01 06:00 [entrez]
AID - 0269881116675515 [pii]
AID - 10.1177/0269881116675515 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2017 Feb;31(2):169-183. doi: 10.1177/0269881116675515. Epub 
      2016 Dec 7.