PMID- 27900264
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2213-5960 (Print)
IS  - 2213-5960 (Electronic)
IS  - 2213-5960 (Linking)
VI  - 11
DP  - 2017 Mar
TI  - A genomic study on distribution of human leukocyte antigen (HLA)-A and HLA-B 
      alleles in Lak population of Iran.
PG  - 3-6
AB  - Anthropological studies based on the highly polymorphic gene, human leukocyte 
      antigen (HLA), provide useful information for bone marrow donor registry, 
      forensic medicine, disease association studies, as well as infertility treatment, 
      designing peptide vaccines against tumors, and infectious or autoimmune diseases. 
      The aim of this study was to determine HLA-A and HLA-B allele frequencies in 100 
      unrelated Lak/lᴂk/individuals from Lorestan province of Iran. Finally, we 
      compared the results with that previously described in Iranian population. 
      Commercial HLA-Type kits from BAG (Lich, Germany) company were used for 
      determination of the HLA-A and HLA-B allele frequencies in genomic DNA, based on 
      polymerase chain reaction with sequence specific primer (PCR-SSP) assay. The 
      differences between the populations in distribution of HLA-A and HLA-B alleles 
      were estimated by chi-squared test with Yate's correction. The most frequent 
      HLA-A alleles were *24 (20%), *02 (18%), *03 (12%) and *11 (10%), and the most 
      frequent HLA-B alleles were *35 (24%), *51 (16%), *18 (6%) and *38 (6%) in Lak 
      population. HLA-A*66 (1%), *74(1%) and HLA-B*48 (1%), *55(1%) were the least 
      observed frequencies in Lak population. Our results based on HLA-A and HLA-B 
      allele frequencies showed that Lak population possesses the previously reported 
      general features of Iranians but still with unique.
FAU - Shahsavar, Farhad
AU  - Shahsavar F
AD  - Department of immunology, Lorestan University of Medical Sciences, Khorramabad, 
      Iran.
FAU - Varzi, Ali-Mohammad
AU  - Varzi AM
AD  - Department of immunology, Lorestan University of Medical Sciences, Khorramabad, 
      Iran.
FAU - Ahmadi, Seyyed Amir Yasin
AU  - Ahmadi SA
AD  - Research Office for the History of Persian Medicine, Lorestan University of 
      Medical Sciences, Khorramabad, Iran; Student Research Committee, Lorestan 
      University of Medical Sciences, Khorramabad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20161110
PL  - United States
TA  - Genom Data
JT  - Genomics data
JID - 101634120
PMC - PMC5122700
OTO - NOTNLM
OT  - Anthropology
OT  - HLA class I
OT  - Immunology
OT  - Iran
OT  - Lak population
EDAT- 2016/12/03 06:00
MHDA- 2016/12/03 06:01
PMCR- 2016/11/10
CRDT- 2016/12/01 06:00
PHST- 2016/09/25 00:00 [received]
PHST- 2016/11/03 00:00 [revised]
PHST- 2016/11/09 00:00 [accepted]
PHST- 2016/12/01 06:00 [entrez]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2016/12/03 06:01 [medline]
PHST- 2016/11/10 00:00 [pmc-release]
AID - S2213-5960(16)30170-2 [pii]
AID - 10.1016/j.gdata.2016.11.012 [doi]
PST - epublish
SO  - Genom Data. 2016 Nov 10;11:3-6. doi: 10.1016/j.gdata.2016.11.012. eCollection 
      2017 Mar.