PMID- 27903510
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20200930
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 312
IP  - 1
DP  - 2017 Jan 1
TI  - Vitamin D supplementation reduces some AT1-AA-induced downstream targets 
      implicated in preeclampsia including hypertension.
PG  - R125-R131
LID - 10.1152/ajpregu.00218.2016 [doi]
AB  - Autoantibodies to the ANG II type I receptor (AT(1)-AA) are associated with 
      preeclampsia (PE). We found that vitamin D supplementation reduced AT(1)-AA and 
      blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined 
      whether the decrease in AT(1)-AA was the mechanism whereby vitamin D lowered MAP 
      or if it were through factors downstream of AT(1)-AA. Uterine artery resistance 
      index, placental ET-1, and soluble FMS-like tyrosine kinase-1 are increased with 
      AT(1)-AA-induced hypertension and are considered markers of PE in pregnant women. 
      Therefore, we hypothesized that vitamin D would reduce PE factors during 
      AT(1)-AA-induced hypertension and could lower blood pressure in a model of 
      hypertension during pregnancy without PE features. Either ANG II (50 
      ng.kg(-1).day) or AT(1)-AA (1:40) was infused from gestational day (GD) 12-19. 
      vitamin D(2) (VD2, 270 IU/day) or vitamin D(3) (VD3, 15 IU/day) was administered 
      orally from GD14-GD18. MAP (mmHg) increased in AT(1)-AA (121 +/- 4) and ANG II (113 
      +/- 1)-infused pregnant rats compared with normal pregnant rats (NP) (101 +/- 2) but 
      was lower in AT(1)-AA+VD2 (105 +/- 2), AT(1)-AA+VD3 (109 +/- 2), ANG II+VD2 (104 +/- 
      4), and ANG II+VD3 (104 +/- 3). VD2 and/or VD3 improved PE features associated with 
      AT(1)-AA during pregnancy, while ANG II did not induce such features, supporting 
      the hypothesis that AT(1)-AA induces PE features during pregnancy, and these are 
      improved with vitamin D. In this study, we demonstrate that vitamin D improved 
      many factors associated with PE and reduced blood pressure in a hypertensive 
      model without PE features, indicating that vitamin D could be beneficial for 
      various hypertensive disorders of pregnancy.
CI  - Copyright (c) 2017 the American Physiological Society.
FAU - Faulkner, Jessica L
AU  - Faulkner JL
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Amaral, Lorena M
AU  - Amaral LM
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Cornelius, Denise C
AU  - Cornelius DC
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Cunningham, Mark W
AU  - Cunningham MW
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Ibrahim, Tarek
AU  - Ibrahim T
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Heep, Autumn
AU  - Heep A
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Campbell, Nathan
AU  - Campbell N
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Usry, Nathan
AU  - Usry N
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi.
FAU - Wallace, Kedra
AU  - Wallace K
AD  - Department of Obstetrics and Gynecology, University of Mississippi Medical 
      Center, Jackson, Mississipppi.
FAU - Herse, Florian
AU  - Herse F
AD  - Experimental and Clinical Research Center, Charite Campus Buch and Max-Delbruck 
      Center for Molecular Medicine, Berlin, Germany; and.
FAU - Dechend, Ralf
AU  - Dechend R
AD  - Experimental and Clinical Research Center, Charite Campus Buch and Max-Delbruck 
      Center for Molecular Medicine, Berlin, Germany; and.
AD  - HELIOS Clinic, Department of Cardiology and Nephrology, Berlin, Germany.
FAU - LaMarca, Babbette
AU  - LaMarca B
AD  - Department of Pharmacology and Toxicology, University of Mississippi Medical 
      Center, Jackson, Mississippi; bblamarca@umc.edu.
AD  - Department of Obstetrics and Gynecology, University of Mississippi Medical 
      Center, Jackson, Mississipppi.
LA  - eng
GR  - P01 HL051971/HL/NHLBI NIH HHS/United States
GR  - P20 GM104357/GM/NIGMS NIH HHS/United States
GR  - R01 HD067541/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20161130
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Blood Pressure/drug effects/*immunology
MH  - *Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Pre-Eclampsia/*drug therapy/*physiopathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Angiotensin, Type 1/*immunology
MH  - Treatment Outcome
MH  - Vitamin D/*administration & dosage
PMC - PMC5283941
OTO - NOTNLM
OT  - hypertension
OT  - inflammation
OT  - pregnancy
EDAT- 2016/12/03 06:00
MHDA- 2017/06/27 06:00
PMCR- 2018/01/01
CRDT- 2016/12/02 06:00
PHST- 2016/05/23 00:00 [received]
PHST- 2016/11/09 00:00 [revised]
PHST- 2016/11/09 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2016/12/02 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - ajpregu.00218.2016 [pii]
AID - R-00218-2016 [pii]
AID - 10.1152/ajpregu.00218.2016 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2017 Jan 1;312(1):R125-R131. doi: 
      10.1152/ajpregu.00218.2016. Epub 2016 Nov 30.