PMID- 27904163
OWN - NLM
STAT- MEDLINE
DCOM- 20180424
LR  - 20181113
IS  - 0011-7781 (Print)
IS  - 0011-7781 (Linking)
VI  - 88
IP  - 9
DP  - 2016 Sep
TI  - The Impact of Direct Cardiac Output Determination On Using A Widely Available 
      Direct Continuous Oxygen Consumption Measuring Device On The Hemodynamic 
      Assessment of Aortic Valve.
PG  - 270-275
AB  - BACKGROUND: Accurate assessment of cardiac output (CO) is essential for the 
      hemodynamic assessment of aortic valve area (AVA). Estimation of oxygen 
      consumption (VO2) and Thermodilution (TD) is employed in many cardiac 
      catheterization laboratories (CCL) given the historically cumbersome nature of 
      direct continuous VO2 measurement, the "gold standard" for this technique. A 
      portable facemask device simplifies the direct continuous measurement of VO2, 
      allowing for relatively rapid and continuous assessment of CO and AVA. METHODS 
      AND MATERIALS: Seventeen consecutive patients undergoing right heart 
      catheterization had simultaneous determination of CO by both direct continuous 
      and assumed VO2 and TD. Assessments were only made when a plateau of VO2 had 
      occurred. All measurements of direct continuous and assumed VO2, as well as, TD 
      CO were obtained in triplicate. RESULTS: Direct continuous VO2 CO and assumed VO2 
      CO correlated poorly (R= 0.57; ICC =0.59). Direct continuous VO2 CO and TD CO 
      also correlated poorly (R= 0.51; ICC=0.60). Similarly AVA derived from direct 
      continuous VO2 correlated poorly with those of assumed VO2 (R= 0.68; ICC=0.55) 
      and TD (R=0.66, ICC=0.60). Repeated direct continuous VO2 CO and AVA measurements 
      were extremely correlated and reproducible [(R=0.93; ICC=0.96) and (R=0.99; 
      ICC>0.99) respectively], suggesting that this was the most reliable measurement 
      of CO. CONCLUSIONS: CO calculated from direct continuous VO2 measurement varies 
      substantially from both assumed VO2 and TD based CO, which are widely used in 
      most CCL. These differences may significantly impact the CO and AVA measurements. 
      Furthermore, continuous, rather than average, measurement of VO2 appears to give 
      highly reproducible results.
FAU - Fanari, Zaher
AU  - Fanari Z
AD  - Division of Cardiology, University of Kansas School of Medicine, Kansas City, KS, 
      USA.
FAU - Grove, Matthew
AU  - Grove M
AD  - Section of Cardiology, Carolina East Medical Center, New Bern, NC, USA.
FAU - Rajamanickam, Anitha
AU  - Rajamanickam A
AD  - Division of Cardiology, Mount Sinai Heart, New York, NY, USA.
FAU - Hammami, Sumaya
AU  - Hammami S
AD  - Section of Cardiology, Christiana Care Health System, Newark, DE, USA.
FAU - Walls, Cassie
AU  - Walls C
AD  - Section of Cardiology, Christiana Care Health System, Newark, DE, USA.
FAU - Kolm, Paul
AU  - Kolm P
AD  - Value Institute, Christiana Care Health System, Newark, DE, USA.
FAU - Saltzberg, Mitchell
AU  - Saltzberg M
AD  - Section of Cardiology, Christiana Care Health System, Newark, DE, USA.
FAU - Weintraub, William S
AU  - Weintraub WS
AD  - Section of Cardiology, Christiana Care Health System, Newark, DE, USA; Value 
      Institute, Christiana Care Health System, Newark, DE, USA.
FAU - Doorey, Andrew J
AU  - Doorey AJ
AD  - Section of Cardiology, Christiana Care Health System, Newark, DE, USA; Value 
      Institute, Christiana Care Health System, Newark, DE, USA.
LA  - eng
GR  - U54 GM104941/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Del Med J
JT  - Delaware medical journal
JID - 0370077
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/*physiopathology
MH  - Cardiac Catheterization/*instrumentation/methods
MH  - Cardiac Output/*physiology
MH  - Female
MH  - Heart Function Tests/instrumentation
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/*physiology
PMC - PMC5125626
MID - NIHMS811572
OTO - NOTNLM
OT  - Aortic valve area
OT  - Assumed Oxygen Consumption
OT  - Cardiac Output
OT  - Direct continuous Oxygen Consumption
OT  - Thermodilution
COIS- All authors reports no conflict of interest to disclose.
EDAT- 2016/12/03 06:00
MHDA- 2018/04/25 06:00
PMCR- 2016/11/28
CRDT- 2016/12/02 06:00
PHST- 2016/12/02 06:00 [entrez]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2018/04/25 06:00 [medline]
PHST- 2016/11/28 00:00 [pmc-release]
PST - ppublish
SO  - Del Med J. 2016 Sep;88(9):270-275.