PMID- 27904503
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 11
IP  - 10
DP  - 2016 Oct
TI  - Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells 
      in the treatment of Leber's hereditary optic neuropathy.
PG  - 1685-1694
AB  - The Stem Cell Ophthalmology Treatment Study (SCOTS) is currently the 
      largest-scale stem cell ophthalmology trial registered at ClinicalTrials.gov 
      (identifier: NCT01920867). SCOTS utilizes autologous bone marrow-derived stem 
      cells (BMSCs) to treat optic nerve and retinal diseases. Treatment approaches 
      include a combination of retrobulbar, subtenon, intravitreal, intra-optic nerve, 
      subretinal, and intravenous injection of autologous BMSCs according to the nature 
      of the disease, the degree of visual loss, and any risk factors related to the 
      treatments. Patients with Leber's hereditary optic neuropathy had visual acuity 
      gains on the Early Treatment Diabetic Retinopathy Study (ETDRS) of up to 35 
      letters and Snellen acuity improvements from hand motion to 20/200 and from 
      counting fingers to 20/100. Visual field improvements were noted. Macular and 
      optic nerve head nerve fiber layer typically thickened. No serious complications 
      were seen. The increases in visual acuity obtained in our study were encouraging 
      and suggest that the use of autologous BMSCs as provided in SCOTS for 
      ophthalmologic mitochondrial diseases including Leber's hereditary optic 
      neuropathy may be a viable treatment option.
FAU - Weiss, Jeffrey N
AU  - Weiss JN
AD  - Retina Associates of South Florida, 5800 Colonial Drive, Suite 300, Margate, FL, 
      USA.
FAU - Levy, Steven
AU  - Levy S
AUID- ORCID: 0000-0002-9313-3448
AD  - MD Stem Cells, 3 Sylvan Road South, Westport, CT, USA.
FAU - Benes, Susan C
AU  - Benes SC
AD  - The Eye Center of Columbus, The Ohio State University, Columbus, OH, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT01920867
PT  - Journal Article
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC5116851
OTO - NOTNLM
OT  - Leber's hereditary optic neuropathy
OT  - blindness
OT  - bone marrow derived stem cells
OT  - mitochondrial disease
OT  - nerve regeneration
OT  - neural regeneration
OT  - optic neuropathy
OT  - visual loss
COIS- Conflicts of Interest: None declared.
EDAT- 2016/12/03 06:00
MHDA- 2016/12/03 06:01
PMCR- 2016/10/01
CRDT- 2016/12/02 06:00
PHST- 2016/12/02 06:00 [entrez]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2016/12/03 06:01 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - NRR-11-1685 [pii]
AID - 10.4103/1673-5374.193251 [doi]
PST - ppublish
SO  - Neural Regen Res. 2016 Oct;11(10):1685-1694. doi: 10.4103/1673-5374.193251.