PMID- 27904751
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 2052-336X (Print)
IS  - 2052-336X (Electronic)
VI  - 14
DP  - 2016
TI  - Association of serum concentrations of persistent organic pollutants (POPs) and 
      risk of pre-eclampsia: a case-control study.
PG  - 17
LID - 17
AB  - BACKGROUND: There is increasing evidence that persistent organic pollutants 
      (POPs) may contribute to pre-eclampsia. The objective of this study was to 
      evaluate the association between Polychlorinated Biphenyls (PCBs) and 
      Polybrominated Diphenyl Ethers (PBDEs) as POPs with pre-eclampsia. METHODS: This 
      case-control study was performed in the three general university hospitals of 
      Tehran University of Medical Sciences. Serum samples were collected from cases 
      (n = 45) who had diagnosed with preeclampsia and from control samples (n = 70) 
      with normal pregnancy and attended the same hospital for a routine prenatal visit 
      at the third trimester of pregnancy. Pollutants levels were analyzed by Gas 
      Chromatography Mass Spectrometry (GC/MS). RESULTS: Mean participant age was 
      27.3 +/- 5.39 with median 27. As the main independent variable, total POPs 
      manifested with adjusted OR equal to 1.54 (95 % CI: 1.26-1.87, p-value <0.0001), 
      which was significantly associated with pre-eclampsia. The adjusted OR proved a 
      statistically significant association between total PCBs 1.77 (95 % CI: 
      1.34-2.32) and total PBDEs (OR = 2.19; 95 % CI: 1.39-3.45, p-value = 0.001) with 
      pre-eclampsia considering confounding variables (maternal age, pre-pregnancy body 
      mass index (BMI), gestational age, weight gain during pregnancy and total lipids 
      in maternal serum). Finally, pre-pregnancy BMI and weight gain during pregnancy 
      had a positive association with pre-eclampsia and gestational age yielded a 
      negative association with pre-eclampsia in all analysis. CONCLUSION: Our data 
      indicate the association between total POPs, total PBDEs, and total PCBs with 
      pre-eclampsia, even after controlling for the effects of a number of potentially 
      confounding factors. Further investigation about route of exposure and the trend 
      of POPs especially in pregnant women is needed.
FAU - Eslami, Bita
AU  - Eslami B
AD  - Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Malekafzali, Hossein
AU  - Malekafzali H
AD  - Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Rastkari, Noushin
AU  - Rastkari N
AD  - Center for Air Pollution Research (CAPR), Institute for Environmental Research 
      (IER), Tehran University of Medical Sciences, 8th Floor, No. 1547, North Kargar 
      Ave., Enghelab Square, Tehran, I.R. Iran.
FAU - Rashidi, Batool Hossein
AU  - Rashidi BH
AD  - Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Djazayeri, Abolghasem
AU  - Djazayeri A
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Naddafi, Kazem
AU  - Naddafi K
AD  - Center for Air Pollution Research (CAPR), Institute for Environmental Research 
      (IER), Tehran University of Medical Sciences, 8th Floor, No. 1547, North Kargar 
      Ave., Enghelab Square, Tehran, I.R. Iran.
LA  - eng
PT  - Journal Article
DEP - 20161124
PL  - England
TA  - J Environ Health Sci Eng
JT  - Journal of environmental health science & engineering
JID - 101613643
PMC - PMC5121940
OTO - NOTNLM
OT  - Case-control study
OT  - Persistent Organic pollutants (POPs)
OT  - Polybrominated Diphenyl Ethers (PBDEs)
OT  - Polychlorinated Biphenyls (PCBs)
OT  - Pre-eclampsia
EDAT- 2016/12/03 06:00
MHDA- 2016/12/03 06:01
PMCR- 2016/11/24
CRDT- 2016/12/02 06:00
PHST- 2016/05/26 00:00 [received]
PHST- 2016/10/03 00:00 [accepted]
PHST- 2016/12/02 06:00 [entrez]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2016/12/03 06:01 [medline]
PHST- 2016/11/24 00:00 [pmc-release]
AID - 256 [pii]
AID - 10.1186/s40201-016-0256-9 [doi]
PST - epublish
SO  - J Environ Health Sci Eng. 2016 Nov 24;14:17. doi: 10.1186/s40201-016-0256-9. 
      eCollection 2016.