PMID- 27904855 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2288-6575 (Print) IS - 2288-6796 (Electronic) IS - 2288-6575 (Linking) VI - 91 IP - 6 DP - 2016 Dec TI - Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT. PG - 323-326 AB - The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT). She underwent total parathyroidectomy with video-assisted thoracoscopic surgery on an anterior mediastinal mass. Anterior mediastinal parathyroid adenoma in MEN1 patients is rare. Precise localization of an ectopic parathyroid gland with Tc-99m sestamibi SPECT/CT can lead to successful treatment of hyperparathyroidism. This is the first reported case in the literature of mediastinal parathyroid adenoma in MEN1 patient visualized by Tc-99m sestamibi SPECT/CT. FAU - Park, Hye Lim AU - Park HL AD - Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Yoo, Ie Ryung AU - Yoo IR AD - Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Kim, Sung Hoon AU - Kim SH AD - Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Lee, Sohee AU - Lee S AD - Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. LA - eng PT - Case Reports DEP - 20161125 PL - Korea (South) TA - Ann Surg Treat Res JT - Annals of surgical treatment and research JID - 101622895 PMC - PMC5128379 OTO - NOTNLM OT - Multiple endocrine neoplasia type 1 OT - Parathyroid neoplasms OT - Single-photon emission-computed tomography OT - Technetium-99m sestamibi COIS- No potential conflict of interest relevant to this article was reported. EDAT- 2016/12/03 06:00 MHDA- 2016/12/03 06:01 PMCR- 2016/12/01 CRDT- 2016/12/02 06:00 PHST- 2016/05/10 00:00 [received] PHST- 2016/06/28 00:00 [revised] PHST- 2016/06/28 00:00 [accepted] PHST- 2016/12/02 06:00 [entrez] PHST- 2016/12/03 06:00 [pubmed] PHST- 2016/12/03 06:01 [medline] PHST- 2016/12/01 00:00 [pmc-release] AID - 10.4174/astr.2016.91.6.323 [doi] PST - ppublish SO - Ann Surg Treat Res. 2016 Dec;91(6):323-326. doi: 10.4174/astr.2016.91.6.323. Epub 2016 Nov 25.