PMID- 27906425
OWN - NLM
STAT- MEDLINE
DCOM- 20170731
LR  - 20180318
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 20
IP  - 22
DP  - 2016 Nov
TI  - The correlation between children's status asthmatics and interstitial lung 
      disease.
PG  - 4761-4765
LID - 11785 [pii]
AB  - OBJECTIVE: Investigating the correlation between children's status asthmatics and 
      interstitial lung disease (ILD). PATIENTS AND METHODS: We continuously selected 
      20 cases of children's status asthmatics combined with ILD (group A), 20 cases of 
      pure status asthmatics (group B), 20 cases of pure ILD (group C) and 20 cases of 
      healthy children (group D). We measured Th1/Th2 by flow cytometry as well as the 
      level of expression of hs-CRP, IL-7 cytokines (TSLP), monocyte chemoattractant 
      protein-1 (MCP-1) and anti-Jo-1 antibody by ELISA method. RESULTS: Th1 and 
      Th1/Th2 of groups A and B were significantly lower than those of group C and D. 
      Th2 was significantly (p<0.05) higher than that of groups C and D. The level of 
      expression of hs-CRP, TSLP, MCP-1 and anti-Jo-1 antibody in the groups A and B 
      were all significantly higher (p<0.05) than those of groups C and D. There were 
      differences of the above index of the comparison between groups A and B, but no 
      difference between groups C and D. CONCLUSIONS: Children's status asthmatics and 
      ILD may correlate with the abnormal expression of Th1/Th2, hs-CRP, TSLP, MCP-1 
      and anti-Jo-1 antibody.
FAU - Han, X-M
AU  - Han XM
AD  - Department of Pediatrics, Laiyang Central Hospital, Yantai City, Shandong 
      Province, China. xuemei_han1@163.co.
FAU - Cheng, Y-Y
AU  - Cheng YY
FAU - Gong, Y-F
AU  - Gong YF
FAU - Jiang, M-M
AU  - Jiang MM
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Jo-1 antibody)
SB  - IM
MH  - Antibodies, Antinuclear
MH  - Asthma/*immunology/metabolism
MH  - Chemokine CCL2
MH  - Child
MH  - Humans
MH  - Lung Diseases, Interstitial/*immunology/metabolism
EDAT- 2016/12/03 06:00
MHDA- 2017/08/02 06:00
CRDT- 2016/12/02 06:00
PHST- 2016/12/02 06:00 [entrez]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/08/02 06:00 [medline]
AID - 11785 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2016 Nov;20(22):4761-4765.