PMID- 27908204
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20170911
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 52
IP  - 4
DP  - 2017 Apr
TI  - Clinical implications of serial versus isolated biliary fluorescence in situ 
      hybridization (FISH) polysomy in primary sclerosing cholangitis.
PG  - 377-381
LID - 10.1080/00365521.2016.1263681 [doi]
AB  - BACKGROUND: Cholangiocarcinoma (CCA) is a leading cause of death in patients with 
      primary sclerosing cholangitis (PSC). Biliary polysomy detected by fluorescence 
      in situ hybridization (FISH) helps to identify patients with early CCA, but not 
      all PSC patients with polysomy develop CCA. Here, we examined the features and 
      clinical outcomes of PSC patients with serial versus isolated polysomy. METHODS: 
      All patients with PSC who underwent >/=1 endoscopic retrograde cholangiography 
      (ERC) with FISH testing at Mayo Clinic, Rochester from 2008-2011 were identified. 
      Patients diagnosed with CCA at the time of initial polysomy were excluded. Serial 
      polysomy was defined as polysomy on >/=2 ERCs; isolated polysomy was defined as 
      polysomy once followed by all nonpolysomy results. The primary outcome was the 
      diagnosis of CCA. RESULTS: Twenty-seven patients with polysomy and >/=1 subsequent 
      ERC with FISH were identified. Of these, 11 (40.7%) had serial polysomy and 16 
      (59.3%) had isolated polysomy. CCA was more likely to be diagnosed in patients 
      with serial versus isolated polysomy (36.4% vs. 6.3%; p = .046). Overall, four 
      patients (36.4%) with serial polysomy and three (18.8%) with isolated polysomy 
      underwent liver transplantation (LT), with time to LT being significantly shorter 
      for the former (14.0 vs. 65.4 months; p = .0003). CONCLUSIONS: Biliary polysomy 
      reverted in >/=50% of patients with PSC; this group appears to be at decreased risk 
      of CCA compared to those with serial polysomy. Nevertheless, both groups should 
      be followed closely, and those with serial polysomy may benefit from early LT 
      evaluation.
FAU - Quinn, Kevin P
AU  - Quinn KP
AD  - a Department of Internal Medicine , Mayo Clinic , Rochester , MN , USA.
FAU - Tabibian, James H
AU  - Tabibian JH
AD  - a Department of Internal Medicine , Mayo Clinic , Rochester , MN , USA.
AD  - b Division of Gastroenterology, Department of Medicine , University of 
      Pennsylvania , PA , USA.
FAU - Lindor, Keith D
AU  - Lindor KD
AD  - c College of Health Solutions , University of Arizona , Phoenix , AZ , USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20161201
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - Bile Duct Neoplasms/*diagnosis/genetics
MH  - Bile Ducts, Intrahepatic/*pathology
MH  - Cholangiocarcinoma/*diagnosis/genetics
MH  - Cholangiopancreatography, Endoscopic Retrograde
MH  - Cholangitis, Sclerosing/*complications/*pathology
MH  - Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Liver Transplantation/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tetrasomy
MH  - Trisomy
MH  - United States
OTO - NOTNLM
OT  - Cholangiocarcinoma
OT  - hepatobiliary
OT  - liver transplant
OT  - polysomy
OT  - primary sclerosing cholangitis
EDAT- 2016/12/03 06:00
MHDA- 2017/09/12 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - 10.1080/00365521.2016.1263681 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2017 Apr;52(4):377-381. doi: 
      10.1080/00365521.2016.1263681. Epub 2016 Dec 1.